Schölermann K H, Dettmann R, Hartmann M
Abteilung für Urologie, Bundeswehrkrankenhaus Hamburg.
Urologe A. 1996 Jul;35(4):326-30.
Results in 503 patients with germ cell testicular tumors treated between 1982 and 1992 were analyzed. A follow-up program for germ cell tumors is presented which is related to the individual risk of tumor relapse. The overall relapse rate was 7%, of which 82% had recurrent tumor within 1 year after treatment. A low risk of relapse (3-5%) is seen in patients with seminoma stage I and radiation and, usually, in early-stage patients treated with polychemotherapy. A moderate risk of relapse (6-11%) is observed in patients with non-seminoma stage I and lymphadenectomy without chemotherapy. Seminoma without radiation and non-seminoma without lymphadenectomy in clinical stage I, non-seminoma stage IIa and IIb without adjuvant chemotherapy after lymphadenectomy, and primary high tumor mass present a high risk of relapse (> 11%). Tumor recurrence is localized mainly in lung and retroperitoneum. Most important in the follow-up are tumor marker and chest X-ray. During the first year examinations should take place every 3 months in the low-risk group and every 2 months in the moderate and high risk group. Computer tomography is only required in high-risk patients. Usually a 3-year follow-up is sufficient.
对1982年至1992年间接受治疗的503例睾丸生殖细胞肿瘤患者的结果进行了分析。本文介绍了一种针对生殖细胞肿瘤的随访方案,该方案与肿瘤复发的个体风险相关。总体复发率为7%,其中82%在治疗后1年内出现肿瘤复发。在I期精原细胞瘤且接受放疗的患者中,以及通常在接受多药化疗的早期患者中,复发风险较低(3%-5%)。在I期非精原细胞瘤且接受淋巴结清扫但未化疗的患者中,观察到复发风险中等(6%-11%)。I期临床中未接受放疗的精原细胞瘤和未接受淋巴结清扫的非精原细胞瘤、IIa期和IIb期非精原细胞瘤在淋巴结清扫后未接受辅助化疗以及原发性高肿瘤肿块,复发风险较高(>11%)。肿瘤复发主要局限于肺部和腹膜后。随访中最重要的是肿瘤标志物和胸部X光检查。在第一年,低风险组每3个月进行一次检查,中高风险组每2个月进行一次检查。仅高风险患者需要进行计算机断层扫描。通常3年的随访就足够了。