Lisý O, Vojácek J
II. interní klinika 1. LF UK, Praha.
Vnitr Lek. 1996 Jun;42(6):432-6.
Endothelin, one of the most important vasoconstrictor substances produced by endothelial cells plays along with NO an important role in maintaining the vascular tonus and influencing the vasomotorics of coronary vessels and myocardial perfusion. Damage of the vascular endothelium upsets the dynamic balance between the action of vasoconstrictor and vasodilator substances. In the submitted review the authors discuss the influence of endothelin on cardiomyocytes, the cardiac conduction system and the coronary arteries. The authors emphasize the action of endothelin in atherosclerotically altered coronary arteries, in hypercholesterolaemia and arterial hypertension. Endothelin plays an important role in unstable angina pectoris, cardiogenic shock advanced congestive heart failure and myocardial infarction. In the conclusion the author discuss studies investigating the relationship of percutaneous transluminal coronary angioplasty and the endothelin release into the circulation.
内皮素是内皮细胞产生的最重要的血管收缩物质之一，它与一氧化氮一起在维持血管张力、影响冠状动脉血管舒缩功能和心肌灌注方面发挥重要作用。血管内皮损伤会破坏血管收缩物质和血管舒张物质作用之间的动态平衡。在本综述中，作者讨论了内皮素对心肌细胞、心脏传导系统和冠状动脉的影响。作者强调了内皮素在动脉粥样硬化性改变的冠状动脉、高胆固醇血症和动脉高血压中的作用。内皮素在不稳定型心绞痛、心源性休克、晚期充血性心力衰竭和心肌梗死中起重要作用。在结论部分，作者讨论了关于经皮腔内冠状动脉成形术与内皮素释放进入循环之间关系的研究。
