Anisimov V N, Popovich I G, Muratov E I
Vopr Onkol. 1996;42(4):40-4.
Fifteen doses of 21 mg/kg body weight of 1,2-dimethylhydrazine (DMH) were injected into 48 female rats at one-week intervals. Controls included 25 animals while 23 received 20 mg/l of melatonin with drinking water, 5 times a week, at night-time, for 6 months, beginning from the day of the first injection. Although malignancies of large bowel developed in all animals, multiple tumors in the melatonin group were significantly fewer than in the rats treated with DMH alone (6,0 and 9,9 respectively; p < 0,001). Similarly, melatonin treatment was followed by a significantly lower frequency of tumor development in the ascending colon as well as fewer multiple neoplasms of the ascending and descending colon. Melatonin was also shown to inhibit carcinogenesis in the small intestine. It is suggested that the antitumor effects of melatonin is due to its antioxidant properties.
以一周的间隔向48只雌性大鼠注射15剂体重21 mg/kg的1,2 - 二甲基肼（DMH）。对照组包括25只动物，而23只动物从首次注射之日起，每周5次在夜间饮用含20 mg/l褪黑素的水，持续6个月。尽管所有动物都发生了大肠恶性肿瘤，但褪黑素组的多发性肿瘤明显少于仅用DMH治疗的大鼠（分别为6.0和9.9；p < 0.001）。同样，褪黑素治疗后升结肠肿瘤发生频率显著降低，升结肠和降结肠的多发性肿瘤也较少。褪黑素还被证明能抑制小肠的致癌作用。有人认为褪黑素的抗肿瘤作用归因于其抗氧化特性。
