Hörl W H
Klinischen Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Wien.
Wien Med Wochenschr. 1996;146(11):231-4; discussion 234-5.
Renal diseases as glomerulonephritis, diabetic nephropathy, interstitial nephritis (e.g. analgetic nephropathy) or systemic disease with renal involvement are responsible for renal hypertension. High blood pressure remains the most important factor for progression of chronic renal failure. On the other hand, effective anti-hypertensive therapy results in inhibition of progression. Clinical and experimental studies show a renoprotective effect of ACE inhibitors due to lowering of systemic blood pressure, reduction of glomerular capillary pressure, reduction of proteinuria and antiproliferative effects.
诸如肾小球肾炎、糖尿病肾病、间质性肾炎（如镇痛药肾病）或累及肾脏的全身性疾病等肾脏疾病是肾性高血压的病因。高血压仍然是慢性肾衰竭进展的最重要因素。另一方面，有效的抗高血压治疗可抑制疾病进展。临床和实验研究表明，由于降低全身血压、降低肾小球毛细血管压力、减少蛋白尿以及具有抗增殖作用，血管紧张素转换酶抑制剂具有肾脏保护作用。
