Schmidt A, Mayer G
Klinischen Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Wien.
Wien Med Wochenschr. 1996;146(16):454-6.
Angiotensin converting enzyme (ACE) inhibitors are used widely in the treatment of hypertension and congestive heart failure. An increasing number of patients with chronic renal failure is treated with ACE inhibitors because of their antiproteinuric effect. In patients with diabetic nephropathy ACE inhibitors also slow the progression of renal failure. Direct drug related nephrotoxic effects, like the induction of proteinuria, glucosuria or an interstitial nephritis are rare events. The often observed reduction of the glomerular filtration rate after the induction of an ACE inhibitor therapy is due to the specific intrarenal action of these agents and therefore not an adverse drug reaction.
血管紧张素转换酶（ACE）抑制剂广泛用于治疗高血压和充血性心力衰竭。由于其抗蛋白尿作用，越来越多的慢性肾衰竭患者接受ACE抑制剂治疗。在糖尿病肾病患者中，ACE抑制剂也可减缓肾衰竭的进展。直接的药物相关肾毒性作用，如诱发蛋白尿、糖尿或间质性肾炎，是罕见事件。ACE抑制剂治疗后经常观察到的肾小球滤过率降低是由于这些药物在肾脏内的特定作用，因此不属于药物不良反应。
