De Donato G, Russo A, Taibah A, Saleh E, Sanna M
Acta Otorhinolaryngol Ital. 1995 Apr;15(2):73-9.
Unilateral or asymetrical sensorineural hearing loss, tinnitus and instability classically represent the main symptoms for the suspected diagnosis of acoustic neurinoma. In literature there are very few studies which refer about acoustic neurinoma in patients with normal hearing. In this article we report the results of a retrospective analysis of 155 acoustic neurinoma cases with normal hearing managed in our center in the last 7 years. These patients are classified in two groups: 1) with normal hearing at the time of diagnosis and 2) with at least a mild sensorineural hearing loss. Of this 155 cases, 21 (13.5%) had normal pure tone audiogram. An important characteristic of these patients, in comparison with the group with normal hearing, is the younger age. Tinnitus, instability, sudden hearing loss with complete recovery and vertigo are the most common symptoms. The mean pure tone threshold is 14.7 dB, speech audiometry is positive in very few cases, while a large number of cases show false negative. ABR are positive in 90.5% of cases, and demonstrate its high sensitivity for retrococlear pathology. The mean tumor size shows significant differences between the group with normal hearing and this with hearing loss. We believe that the presence of this symptoms in a young patient should necessitate complete neurotologic examination and in the patients with normal hearing a high level of suspicion represents the first step for early diagnosis of small tumors; the next step is the through evaluation of patient with pure tone audiogram, ABR, and imaging studies, preferably MRI with gadolinium, as this permits the diagnosis of small intracanalicular tumor. Thus, in cases of small tumors with good hearing we feel that will be possible to adopt hearing conservation surgical approach like FCM and retrosigmoid approach in more cases.
单侧或不对称性感音神经性听力损失、耳鸣和平衡失调是疑似听神经瘤诊断的典型主要症状。文献中很少有关于听力正常患者听神经瘤的研究。在本文中,我们报告了对过去7年在我们中心治疗的155例听力正常的听神经瘤病例进行回顾性分析的结果。这些患者分为两组:1)诊断时听力正常;2)至少有轻度感音神经性听力损失。在这155例病例中,21例(13.5%)纯音听力图正常。与听力正常组相比,这些患者的一个重要特征是年龄较小。耳鸣、平衡失调、突发性听力损失且完全恢复以及眩晕是最常见的症状。平均纯音阈值为14.7dB,言语测听在极少数情况下为阳性,而大量病例显示为假阴性。听性脑干反应(ABR)在90.5%的病例中为阳性,表明其对蜗后病变具有高敏感性。听力正常组和听力损失组的平均肿瘤大小存在显著差异。我们认为,年轻患者出现这些症状应进行全面的耳科检查,对于听力正常的患者,高度怀疑是早期诊断小肿瘤的第一步;下一步是通过纯音听力图、ABR和影像学检查,最好是钆增强磁共振成像(MRI)对患者进行全面评估,因为这有助于诊断小的内耳道肿瘤。因此,对于听力良好的小肿瘤病例,我们认为在更多情况下有可能采用如面神经监护(FCM)和乙状窦后入路等保留听力的手术方法。