在支持广泛不同生长特性的培养基中生长的金黄色葡萄球菌（伍德46株）产生的α毒素和总细胞外蛋白增加模式的比较。
Comparison of the patterns of increased in alpha-toxin and total extracellular protein by Staphylococcus aureus (Wood 46) grown in media supporting widely differing growth characteristics.
作者信息
Coleman G, Abbas-Ali B
出版信息
Infect Immun. 1977 Aug;17(2):278-81. doi: 10.1128/iai.17.2.278-281.1977.
Abstract
A comparison has been made of total exoprotein formation by Staphylococcus aureus (Wood 46) in a tryptone soya broth (TSB) medium and a casein hydrolysate-yeast extract-containing (CCY) medium in which exponential growth occurred with doubling times of 3.0 and 1.3 h, respectively. It was found that the differential rate of exoprotein formation was biphasic in each case, increasing after the cessation of exponential growth by a factor of 4 in TSB and 7 in CCY medium. Although this relative change was greater in CCY medium, the maximum value of the differential rate was less than 40% of that achieved in TSB medium. It was further shown that throughout the growth cycle, and in both cultures, alpha-toxin accounted for the same proportion of total extracellular protein.
摘要
对金黄色葡萄球菌（伍德46株）在胰蛋白胨大豆肉汤（TSB）培养基和含酪蛋白水解物 - 酵母提取物（CCY）的培养基中总外蛋白形成情况进行了比较。在这两种培养基中，金黄色葡萄球菌呈指数生长，其倍增时间分别为3.0小时和1.3小时。结果发现，每种情况下外蛋白形成的微分速率都是双相的，在指数生长停止后，TSB培养基中增加了4倍，CCY培养基中增加了7倍。虽然这种相对变化在CCY培养基中更大，但微分速率的最大值不到TSB培养基中所达到值的40%。进一步表明，在整个生长周期以及两种培养物中，α - 毒素在总细胞外蛋白中所占比例相同。
相似文献
1
Comparison of the patterns of increased in alpha-toxin and total extracellular protein by Staphylococcus aureus (Wood 46) grown in media supporting widely differing growth characteristics.在支持广泛不同生长特性的培养基中生长的金黄色葡萄球菌（伍德46株）产生的α毒素和总细胞外蛋白增加模式的比较。
Infect Immun. 1977 Aug;17(2):278-81. doi: 10.1128/iai.17.2.278-281.1977.
2
The characteristics of extracellular protein secretion by Staphylococcus aureus (Wood 46) and their relationship to the regulation of alpha-toxin formation.金黄色葡萄球菌（伍德46株）细胞外蛋白分泌的特性及其与α-毒素形成调节的关系。
J Gen Microbiol. 1977 Apr;99(2):277-82. doi: 10.1099/00221287-99-2-277.
3
A comparison of the patterns of extracellular proteins produced by the high alpha-toxin-secreting organism Staphylococcus aureus (Wood 46) during aerobic and anaerobic growth.
J Gen Microbiol. 1985 Feb;131(2):405-8. doi: 10.1099/00221287-131-2-405.
4
The effect of glucose on the differential rates of extracellular protein and alpha-toxin formation by Staphylococcus aureus (Wood 46).葡萄糖对金黄色葡萄球菌（伍德46株）细胞外蛋白和α-毒素形成的差异速率的影响
Arch Microbiol. 1983 Jun;134(3):208-11. doi: 10.1007/BF00407759.
5
The patterns of extracellular protein formation by spontaneously-occurring rifampicin-resistant mutants of Staphylococcus aureus.
FEMS Microbiol Lett. 1990 Jun 15;58(1):91-4. doi: 10.1016/0378-1097(90)90108-3.
6
Pleiotropic compensation in the regulation of extracellular protein formation by a low alpha-toxin-producing variant of Staphylococcus aureus (Wood 46).金黄色葡萄球菌低α毒素产生变体（伍德46株）对细胞外蛋白质形成调控中的多效性补偿
J Gen Microbiol. 1981 Jan;122(1):11-5. doi: 10.1099/00221287-122-1-11.
7
Staphylococcus aureus S-6: factors affecting its growth, enterotoxin B production and exoprotein formation.金黄色葡萄球菌S-6：影响其生长、肠毒素B产生及外蛋白形成的因素
J Appl Bacteriol. 1991 Apr;70(4):344-50. doi: 10.1111/j.1365-2672.1991.tb02947.x.
8
The effect of glucose on the expression of extracellular protein genes by Staphylococcus aureus strain V8.葡萄糖对金黄色葡萄球菌V8菌株细胞外蛋白基因表达的影响。
FEMS Microbiol Lett. 1989 Oct 15;52(3):247-50. doi: 10.1016/0378-1097(89)90205-x.
9
Effect of trace metals on synthesis of exoproteins and exotoxins by Staphylococcus aureus.
Indian J Exp Biol. 1995 Jun;33(6):416-9.
10
Correlation between the production of alpha-toxin and growth rate in Staphylococcus aureus.金黄色葡萄球菌中α-毒素产生与生长速率之间的相关性
Microbiol Immunol. 1983;27(4):389-94. doi: 10.1111/j.1348-0421.1983.tb00597.x.
引用本文的文献
1
Loratadine decreases virulence of methicillin-resistant by widespread disruption of hemolysis in both Stk1-dependent and -independent fashions.氯雷他定通过以依赖和不依赖Stk1的方式广泛破坏溶血作用来降低耐甲氧西林菌的毒力。
bioRxiv. 2025 Jun 5:2025.06.05.657702. doi: 10.1101/2025.06.05.657702.
2
Novel anti-virulence compounds disrupt exotoxin expression in MRSA.新型抗毒力化合物可破坏耐甲氧西林金黄色葡萄球菌中的外毒素表达。
Microbiol Spectr. 2024 Oct 21;12(12):e0146424. doi: 10.1128/spectrum.01464-24.
3
Molecular basis of surface anchored protein A deficiency in the Staphylococcus aureus strain Wood 46.金黄色葡萄球菌伍德46株表面锚定蛋白A缺陷的分子基础。
PLoS One. 2017 Aug 31;12(8):e0183913. doi: 10.1371/journal.pone.0183913. eCollection 2017.
4
Complete Genome Sequence of Strain Wood 46.菌株Wood 46的全基因组序列
Genome Announc. 2017 Mar 30;5(13):e00087-17. doi: 10.1128/genomeA.00087-17.
5
The nature of the competitive ability of spontaneous staphylocoagulase-negative mutants of Staphylococcus aureus with respect to growth of the parent strains in continuous culture.金黄色葡萄球菌自发凝固酶阴性突变体相对于亲本菌株在连续培养中的生长竞争能力的本质。
Antonie Van Leeuwenhoek. 1982;48(1):67-83. doi: 10.1007/BF00399489.
6
The effect of glucose on the differential rates of extracellular protein and alpha-toxin formation by Staphylococcus aureus (Wood 46).葡萄糖对金黄色葡萄球菌（伍德46株）细胞外蛋白和α-毒素形成的差异速率的影响
Arch Microbiol. 1983 Jun;134(3):208-11. doi: 10.1007/BF00407759.
7
Cloning of a chromosomal locus (exp) which regulates the expression of several exoprotein genes in Staphylococcus aureus.调控金黄色葡萄球菌中几个外蛋白基因表达的染色体位点（exp）的克隆。
Mol Gen Genet. 1988 Mar;211(3):435-40. doi: 10.1007/BF00425697.
8
Identification and nucleotide sequence of the delta-lysin gene, hld, adjacent to the accessory gene regulator (agr) of Staphylococcus aureus.金黄色葡萄球菌辅助基因调节子（agr）附近的δ-溶血素基因hld的鉴定及核苷酸序列
Mol Gen Genet. 1989 Nov;219(3):480-5. doi: 10.1007/BF00259623.
9
Alpha-toxin of Staphylococcus aureus.金黄色葡萄球菌α毒素
Microbiol Rev. 1991 Dec;55(4):733-51. doi: 10.1128/mr.55.4.733-751.1991.
本文引用的文献
1
EXTRACELLULAR RIBONUCLEASE FORMATION IN BACILLUS SUBTILIS AND ITS STIMULATION BY ACTINOMYCIN D.枯草芽孢杆菌中细胞外核糖核酸酶的形成及其受放线菌素D的刺激
Biochem J. 1965 Jun;95(3):699-706. doi: 10.1042/bj0950699.
2
Isolation and composition of staphylococcal alpha toxin.葡萄球菌α毒素的分离与组成
J Gen Microbiol. 1963 Mar;30:455-68. doi: 10.1099/00221287-30-3-455.
3
Staphylococcal leucocidins.葡萄球菌杀白细胞素
Br J Exp Pathol. 1957 Apr;38(2):123-37.
4
Influence of cultivation conditions on the production of extracellular proteins by Staphylococcus aureus.培养条件对金黄色葡萄球菌细胞外蛋白质产生的影响。
Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;79(3):399-405. doi: 10.1111/j.1699-0463.1971.tb00079.x.
5
Cellular changes accompanying the transition from minimal to maximal rate of extracellular enzyme secretion by Bacillus amyloliquefaciens.解淀粉芽孢杆菌从最低到最高细胞外酶分泌速率转变过程中的细胞变化。
J Appl Bacteriol. 1974 Jun;37(2):225-37. doi: 10.1111/j.1365-2672.1974.tb00434.x.
6
Pleiotropic alteration of activities of several toxins and enzymes in mutants of Staphylococcus aureus.金黄色葡萄球菌突变体中几种毒素和酶活性的多效性改变
J Bacteriol. 1974 Jul;119(1):117-22. doi: 10.1128/jb.119.1.117-122.1974.
7
A model for the regulation of bacterial extracellular enzyme and toxin biosynthesis.一种细菌细胞外酶和毒素生物合成调控模型。
J Theor Biol. 1975 Jul;52(1):143-8. doi: 10.1016/0022-5193(75)90045-4.
Zotero 插件