Shormanov S V, Ial'tsev A V
Arkh Patol. 1996 Jan-Feb;58(1):37-41.
Structural changes of kidney arteries and glomeruli are studied histologically, histochemically and morphometrically in 10 dogs with a hemodynamic model of aorta coarctation, 10 dogs with a corrected defect and 10 control dogs. Decrease of the blood inflow is followed by the development of adaptive, compensatory and pathological vascular changes in the kidney. The first type of changes manifested in the media circular muscles atrophy of the kidney arteries, the second type of changes is a vessel restructuring with formation of blocking arteries. The third is sclerosis of the arterial branches and glomeruli. Surgical removal of the experimental defect is followed by a reverse development of these processes, particularly that of circular muscles atrophy of the vascular wall. Reversibility of compensatory and solerotic changes of arteries and glomeruli proceeds much slower.
对10只患有主动脉缩窄血流动力学模型的犬、10只矫正缺陷犬和10只对照犬的肾动脉和肾小球的结构变化进行了组织学、组织化学和形态计量学研究。肾血流减少后会出现适应性、代偿性和病理性血管变化。第一种变化表现为肾动脉中膜环形肌萎缩,第二种变化是血管重构并形成阻塞性动脉。第三种是动脉分支和肾小球硬化。手术去除实验性缺陷后,这些过程会逆向发展,尤其是血管壁环形肌萎缩的过程。动脉和肾小球的代偿性和硬化性变化的可逆性进展要慢得多。