Kaste S C, Pappo A S, Jenkins J J, Pratt C B
Department of Diagnostic Imaging, St. Jude Children's Research Hospital, 332 N. Lauderdale, P. O. Box 318, Memphis, TN 38101-0318, USA.
Pediatr Radiol. 1996 Nov;26(11):800-5. doi: 10.1007/BF01396205.
The objective of this study was to investigate the role of diagnostic imaging in detecting unsuspected metastatic disease in children with malignant melanoma. This has not been well studied previously.
We correlated imaging findings of 33 children diagnosed with melanoma with the level of invasion and clinical stage of disease.
Clinically undetectable metastases were identified in eight patients (25 %), four of whom had multiple metastases. All eight patients had deep lesions (Clark's level IV or V) or unknown primary sites of disease.
Children with thick melanomas and those with unknown site of primary tumors are at increased risk of having clinically unsuspected metastases and should undergo CT of the chest, abdomen, and local-regional nodal basins at diagnosis to determine disease extent.
本研究的目的是调查诊断性成像在检测恶性黑色素瘤患儿未被怀疑的转移性疾病中的作用。此前对此尚未进行充分研究。
我们将33例诊断为黑色素瘤的患儿的成像结果与疾病的侵袭程度和临床分期进行了关联。
8例患者（25%）发现了临床上无法检测到的转移灶，其中4例有多处转移。所有8例患者均有深部病变（克拉克分级IV级或V级）或疾病原发部位不明。
厚皮黑色素瘤患儿以及原发肿瘤部位不明的患儿发生临床上未被怀疑的转移的风险增加，诊断时应进行胸部、腹部和局部区域淋巴结的CT检查以确定疾病范围。
