Shoemaker D A, Pretty J R, Ramsey D M, McLaurin J L, Khan A, Teass A W, Castranova V, Pailes W H, Dalal N S, Miles P R
Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA.
Scand J Work Environ Health. 1995;21 Suppl 2:15-8.
This study examined the possibility of freshly fractured alpha-quartz being more toxic and inflammatory in vivo than aged quartz of the same composition and particle size. Fresh quartz was generated by a jet mill, and used immediately, while aged dust was stored for two months before use. Both the production of hydrogen peroxide and hydroxyl radicals and the analysis of surface radicals verified the enhanced surface activity of fresh quartz. Male Fischer 344 rats were exposed to fresh or aged alpha-quartz by inhalation (20 mg center dot m-3, 5 h per day, 5 d per week, for 2 weeks) and their pulmonary responses were determined 1--3 d postexposure. Exposure to aged quartz resulted in an increase in cytotoxic and inflammatory parameters. In comparison, the inhalation of freshly cleaved quartz resulted in dramatically greater increases in all of the pulmonary responses. This finding suggests that exposure to freshly machined quartz may result in a greater risk of pulmonary disease.
本研究探讨了新鲜破碎的α-石英在体内是否比相同成分和粒径的老化石英更具毒性和炎症性。新鲜石英由气流粉碎机产生并立即使用，而老化粉尘在使用前储存两个月。过氧化氢和羟基自由基的产生以及表面自由基的分析均证实了新鲜石英表面活性增强。雄性Fischer 344大鼠通过吸入暴露于新鲜或老化的α-石英（20 mg·m-3，每天5小时，每周5天，持续2周），并在暴露后1 - 3天测定其肺部反应。暴露于老化石英导致细胞毒性和炎症参数增加。相比之下，吸入新鲜破碎的石英导致所有肺部反应显著更大程度的增加。这一发现表明，接触新加工的石英可能会增加患肺病的风险。
