Waddington J L, Youssef H A, Farrell M A, Toland J
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Schizophr Res. 1995 Dec;18(1):79-82. doi: 10.1016/0920-9964(95)00064-x.
'Schizophrenia-like' psychosis has not been reported previously as a prodrome of Pick's disease, a dementia of frontotemporal pathology. A woman having a consistent clinical diagnosis of typical schizophrenia who developed increasing affectivity and cognitive deficits was examined by computed tomography and brain biopsy. This presentation was found to be associated with left frontotemporal atrophy, left sylvian fissure abnormalities and enlargement of the anterior and temporal horns of the left lateral ventricle. On biopsy, all the neuropathological hallmarks of Pick's disease were present. Unusually, some specific aspect of Pick's disease in this patient appears initially to have disturbed brain function in a manner reproducing some fundamental aspect(s) of schizophrenia itself; left frontotemporal dysfunction would appear to be a relevant common denominator.
“类精神分裂症”精神病此前尚未被报道为匹克氏病（一种额颞叶病变性痴呆）的前驱症状。一名临床诊断为典型精神分裂症且情感和认知缺陷不断加重的女性接受了计算机断层扫描和脑活检。结果发现，这种表现与左侧额颞叶萎缩、左侧外侧裂异常以及左侧侧脑室前角和颞角扩大有关。活检显示存在匹克氏病所有的神经病理学特征。不同寻常的是，该患者匹克氏病的某些特定方面最初似乎以重现精神分裂症本身某些基本方面的方式扰乱了脑功能；左侧额颞叶功能障碍似乎是一个相关的共同因素。
