Berclaz P Y, Benedek C, Jequier E, Schutz Y
Institute of Physiology, Faculty of Medicine, University of Lausanne, Switzerland.
Pediatr Res. 1996 Mar;39(3):401-9. doi: 10.1203/00006450-199603000-00005.
To explore the changes in resting energy expenditure (REE) and whole body protein turnover induced by malaria, 23 children aged 6 to 14 y (23.9 +/- 1.0 kg, 1.3 +/- 0.02 m) were studied on three separate days after treatment (d 1, d 2, and 15 d later). REE was assessed by indirect calorimetry (hood), whereas whole body protein turnover was estimated using a single dose of [15N]glycine administered p.o. by measuring the isotopic enrichment of [15N]ammonia in urine over 12 h. Within the first 3.5 h after treatment, the body temperature dropped from 39.8 +/- 0.1 to 37.8 +/- 0.1 degrees C (p < 0.0001), and REE followed the same pattern, decreasing rapidly from 223 +/- 6 to 187 +/- 4 kJ/kg/d (p < 0.0001). Whole body protein synthesis and breakdown were significantly higher during the 1st day (5.65 +/- 0.38 and 6.21 +/- 0.43 g/kg/d, respectively) than at d 15 (2.95 +/- 0.17 and 2.77 +/- 0.2 g/kg/d). It is concluded that Gambian children suffering from an acute episode of malaria have an increased REE averaging 37% of the control value (d 15) and that this was associated with a substantial increase (by a factor of 2) in whole body protein turnover. A rapid normalization of the hypermetabolism and protein hypercatabolism states after treatment was observed.
为探究疟疾引起的静息能量消耗（REE）和全身蛋白质周转的变化，对23名6至14岁儿童（体重23.9±1.0kg，身高1.3±0.02m）在治疗后的三个不同时间点（第1天、第2天和15天后）进行了研究。REE通过间接测热法（头罩法）评估，而全身蛋白质周转则通过口服单剂量[15N]甘氨酸进行估计，通过测量12小时内尿液中[15N]氨的同位素富集情况来计算。治疗后的前3.5小时内，体温从39.8±0.1降至37.8±0.1摄氏度（p<0.0001），REE也呈现相同模式，从223±6迅速降至187±4kJ/kg/d（p<0.0001）。第1天的全身蛋白质合成和分解显著高于第15天（分别为5.65±0.38和6.21±0.43g/kg/d）（第15天分别为2.95±0.17和2.77±0.2g/kg/d）。得出的结论是，患有急性疟疾发作的冈比亚儿童REE增加，平均为对照值（第15天）的37%，这与全身蛋白质周转的大幅增加（增加了2倍）有关。治疗后观察到高代谢和蛋白质高分解代谢状态迅速恢复正常。
