制剂对硫磷毒性作用的评估。
Evaluation of the role of formulation on parathion toxicity.
作者信息
Puga F R, Rodrigues M A
机构信息
Instituto Biológico, São Paulo, Brazil.
出版信息
Ecotoxicol Environ Saf. 1996 Oct;35(1):38-40. doi: 10.1006/eesa.1996.0079.
PMID:8930503
Abstract
The influence of the vehicle on the toxicity of parathion was evaluated by determining the oral and dermal LD50 in rats. The assessment of dermal absorption was performed by measuring the inhibition of plasma cholinesterase activity. The test vehicles were arol and xylene. The data obtained indicated that the acute oral and dermal toxicities are higher in xylene than in arol, but no differences were observed on plasma cholinesterase activity.
摘要
通过测定大鼠经口和经皮的半数致死剂量（LD50），评估了溶媒对对硫磷毒性的影响。通过测量血浆胆碱酯酶活性的抑制情况来进行皮肤吸收评估。测试溶媒为芳烃溶剂油和二甲苯。所获得的数据表明，二甲苯中的急性经口和经皮毒性高于芳烃溶剂油，但在血浆胆碱酯酶活性方面未观察到差异。
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