Danielsen B, Fejerskov O, Scheie A A
Dental Auxiliary Division, Royal Dental College, Faculty of Health Sciences, University of Aarhus, Denmark.
Int Dent J. 1996 Apr;46(2):91-6.
The aim of this study was to investigate the efficacy of a pre-brushing rinse containing sodium benzoate and alcohol, on 2 week old dental plaque. In a double-blind, placebo-controlled crossover study 20 individuals abstained from oral hygiene for periods of 2 weeks. Ten individuals were then assigned to rinse once for 30 seconds with either the test mouthrinse or a placebo mouthrinse. Following this, all individuals had their teeth cleaned and maintained proper oral hygiene for four weeks before the experiment was repeated. This time, the control individuals were assigned to the test rinse and vice versa. Using the Plaque Index on three buccal sites on all teeth, plaque was recorded before and after rinsing, as well as following a subsequent toothbrushing. For metabolic studies plaque from the lingual surfaces on the teeth in one quadrant in the upper and the lower jaw was sampled before rinsing and from the two remaining quadrants following the rinse, and analysed. There was no difference in Plaque Index between the two experimental periods. An oral rinse with the test mouthrinse had no effect on the amount of plaque, nor did it enhance the subsequent plaque removal after brushing. The independent biochemical analysis showed a significant effect of rinsing on the glycolytic potential, but with no effect on the glycolytic profile, which was similar for test and control plaque samples. Thus, a single oral rinse with a mouthrinse containing sodium benzoate and alcohol does not affect removal of plaque nor does it seems to influence the glycolytic potential of the plaque.
本研究的目的是调查含有苯甲酸钠和酒精的刷牙前漱口液对两周龄牙菌斑的疗效。在一项双盲、安慰剂对照的交叉研究中,20名受试者停止口腔卫生护理两周。然后,10名受试者被分配用测试漱口水或安慰剂漱口水漱口30秒。在此之后,所有受试者的牙齿都被清洁,并在重复实验前四周保持适当的口腔卫生。这次,对照组受试者被分配使用测试漱口水,反之亦然。使用所有牙齿三个颊侧部位的菌斑指数,在漱口前后以及随后刷牙后记录菌斑情况。对于代谢研究,在漱口前从上下颌一个象限牙齿的舌面采集菌斑样本,在漱口后从其余两个象限采集菌斑样本并进行分析。两个实验阶段的菌斑指数没有差异。用测试漱口水漱口对菌斑量没有影响,也没有增强随后刷牙后的菌斑清除效果。独立的生化分析表明,漱口对糖酵解潜力有显著影响,但对糖酵解谱没有影响,测试和对照菌斑样本的糖酵解谱相似。因此,单次使用含有苯甲酸钠和酒精的漱口水漱口既不会影响菌斑清除,似乎也不会影响菌斑的糖酵解潜力。