Aarnisalo A M, Vainio P J, Männistö P T, Vasar E, Tuominen R K
Department of Pharmacology and Toxicology, University of Helsinki, Finland.
Neuroreport. 1996 Sep 2;7(13):2167-70. doi: 10.1097/00001756-199609020-00022.
We have studied a possible role of cholecystokinin (CCK) in regulating adrenal medullary function. Caerulein (10(-10)-10(-7) M), a CCK receptor agonist, increased formation of inositol phosphates in primary cultured bovine adrenal medullary (BAM) chromaffin cells in a concentration-dependent manner. The effect of caerulein was antagonized by devazepide, a selective CCKA-receptor antagonist, but not by L-365.260, a selective CCKB-receptor antagonist. These results suggest that BAM cells possess functional CCK receptors of the CCKA-subtype. Stimulation of these receptors with caerulein activates a signal transduction pathway via phospholipase C. CCK may regulate catecholamine release in BAM cells.
