Fujisawa M, Miyamoto O, Itano T, Tokuda M, Matsui H, Nagao S, Negi T, Hatase O
Department of Neurosurgery, Kagawa Medical School, Japan.
Eur J Pharmacol. 1993 Jul 6;238(1):127-30. doi: 10.1016/0014-2999(93)90516-k.
The effects and pharmacological mechanisms underlying the inhibiting effect of ceruletide, a cholecystokinin (CCK)-related peptide, on apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats were investigated. For this purpose, selective CCKA and CCKB receptor antagonists were used. Ceruletide (50-400 micrograms/kg, s.c.) dose dependently suppressed apomorphine-induced rotational behavior. The antiapomorphine effect of ceruletide was reversed by the selective CCKA receptor antagonist, devazepide, but not by the selective CCKB receptor antagonist, L-365,260. This suggests that the suppression ceruletide exerts on hyperactive nigrostriatal dopamine neurons is mediated by CCKA receptors.
