Park S B, Williamson D J, Cowen P J
University Department of Psychiatry, Littlemore Hospital, Oxford.
Psychol Med. 1996 Nov;26(6):1191-6. doi: 10.1017/s0033291700035911.
We studied the prolactin and cortisol responses to the 5-HT releasing agent, D-fenfluramine in 31 drug-free depressed patients and 29 healthy controls, using a double-blind, placebo-controlled design. There was no difference in either endocrine response between depressives and controls. Examining the sexes separately, or restricting comparisons to patients with melancholic depression, did not lead to any differences between the groups. Our findings suggest that in contrast to other 5-HT neuroendocrine probes such as L-tryptophan and clomipramine, the prolactin response to fenfluramine are not consistently blunted in depressed patients.
我们采用双盲、安慰剂对照设计，研究了31名未服用药物的抑郁症患者和29名健康对照者对5-羟色胺释放剂D-芬氟拉明的催乳素和皮质醇反应。抑郁症患者和对照组之间的内分泌反应均无差异。分别对性别进行研究，或将比较局限于患有忧郁症的患者，均未导致两组之间出现任何差异。我们的研究结果表明，与其他5-羟色胺神经内分泌探针（如L-色氨酸和氯米帕明）不同，抑郁症患者对芬氟拉明的催乳素反应并非始终减弱。
