慢性携带者家庭成员中的丙型肝炎病毒感染

Hepatitis C virus infection in family members of chronic carriers.

作者信息

De Mercato R, Cantiello J P, Celentano U, Guarnaccia D, Ciannella G

机构信息

University Federico II, Medical School, Naples, Italy.

出版信息

Minerva Med. 1996 Jul-Aug;87(7-8):335-7.

PMID:8931652

Abstract

To determine the transmission of hepatitis C in family members of chronic carriers we study the results of a HCV seroprevalence among spouses and children living together with patients affected by HCV related chronic liver disease. Seroprevalence of HCV antibodies and mean cohabitation time was determined among 54 index patients, their 54 spouses and 99 children. Twelve spouses (22.2%) and no children were anti-HCV positive, with an overall seroprevalence of 7.8%. Couples with both anti-HCV positive partners had a mean cohabitation time (31.8 +/- 10.4 years) higher compared to couples with only one anti-HCV positive partner (24.6 +/- 9.9 years) and children (19.1 +/- 10.2 years). Sexual transmission of HCV infection cannot be excluded and its prevalence is strongly associated to the length of cohabitation time.

摘要

为了确定丙型肝炎在慢性携带者家庭成员中的传播情况，我们研究了与丙型肝炎相关慢性肝病患者共同生活的配偶和子女中丙型肝炎病毒血清流行率的结果。在54例索引患者、他们的54名配偶和99名子女中测定了丙型肝炎病毒抗体的血清流行率和平均同居时间。12名配偶（22.2%）抗-HCV阳性，子女中无抗-HCV阳性者，总体血清流行率为7.8%。双方抗-HCV均阳性的夫妻平均同居时间（31.8±10.4年）高于只有一方抗-HCV阳性的夫妻（24.6±9.9年）和子女（19.1±10.2年）。不能排除丙型肝炎病毒感染的性传播，其流行率与同居时间长短密切相关。