• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

导管原位癌中TP53基因的突变及17号染色体p13区域的等位基因失衡

Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.

作者信息

Munn K E, Walker R A, Menasce L, Varley J M

机构信息

CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.

出版信息

Br J Cancer. 1996 Nov;74(10):1578-85. doi: 10.1038/bjc.1996.592.

DOI:10.1038/bjc.1996.592
PMID:8932338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2074864/
Abstract

A panel of 36 cases of preinvasive breast lesions, including 35 cases of ductal carcinoma in situ (DCIS), has been examined for mutation of TP53, allelic imbalance (AI) on 17p13, and expression of TP53, in a number of cases, has been studied using immunohistochemistry. Areas of DCIS, with or without adjacent invasive or benign cells, have been separately microdissected from paraffin-embedded sections and analysed by PCR for genetic changes to chromosome 17p13. TP53 mutations and AI on 17p have been identified in cases of 'pure' DCIS as well as those with associated invasive carcinoma and, furthermore, have been identified in well-differentiated lesions as well as poorly differentiated ones.

摘要

一组36例乳腺原位癌前病变，包括35例导管原位癌（DCIS），已对其TP53突变、17p13的等位基因失衡（AI）进行检测，并且在一些病例中，已使用免疫组织化学研究了TP53的表达。DCIS区域，无论有无相邻浸润性或良性细胞，均已从石蜡包埋切片中单独显微切割出来，并通过PCR分析17号染色体p13区域的基因变化。在“纯”DCIS病例以及伴有浸润性癌的病例中均已鉴定出TP53突变和17p上的AI，此外，在高分化病变以及低分化病变中也已鉴定出这些情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b18/2074864/60041cebfabc/brjcancer00026-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b18/2074864/b63ba39da291/brjcancer00026-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b18/2074864/b20a2a19ed2a/brjcancer00026-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b18/2074864/60041cebfabc/brjcancer00026-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b18/2074864/b63ba39da291/brjcancer00026-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b18/2074864/b20a2a19ed2a/brjcancer00026-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b18/2074864/60041cebfabc/brjcancer00026-0076-a.jpg

相似文献

1
Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.导管原位癌中TP53基因的突变及17号染色体p13区域的等位基因失衡
Br J Cancer. 1996 Nov;74(10):1578-85. doi: 10.1038/bjc.1996.592.
2
TP53 alterations in atypical ductal hyperplasia and ductal carcinoma in situ of the breast.
Breast Cancer Res Treat. 1996;41(2):103-9. doi: 10.1007/BF01807155.
3
Genetic progression, histological grade, and allelic loss in ductal carcinoma in situ of the breast.乳腺导管原位癌的基因进展、组织学分级及等位基因缺失
Cancer Res. 1996 Nov 15;56(22):5260-5.
4
Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.乳腺导管原位癌中BRCA1基因区域的等位基因失衡。
Br J Cancer. 1996 Mar;73(5):636-9. doi: 10.1038/bjc.1996.110.
5
Characterization of extensive genetic alterations in ductal carcinoma in situ by fluorescence in situ hybridization and molecular analysis.通过荧光原位杂交和分子分析对导管原位癌广泛基因改变的特征描述
J Natl Cancer Inst. 1995 Nov 15;87(22):1694-704. doi: 10.1093/jnci/87.22.1694.
6
Genetic relation of lobular carcinoma in situ, ductal carcinoma in situ, and associated invasive carcinoma of the breast.乳腺小叶原位癌、导管原位癌及相关浸润性癌的遗传关系。
Mol Pathol. 2000 Jun;53(3):118-21. doi: 10.1136/mp.53.3.118.
7
Four regions of allelic imbalance on 17q12-qter associated with high-grade breast tumors.与高级别乳腺肿瘤相关的17号染色体长臂12区至末端的四个等位基因失衡区域。
Genes Chromosomes Cancer. 1997 Dec;20(4):354-62.
8
Technical approach for the study of the genetic evolution of breast cancer from paraffin-embedded tissue sections.
Breast Cancer Res Treat. 1996;39(2):177-85. doi: 10.1007/BF01806184.
9
p53 mutations in mammary ductal carcinoma in situ but not in epithelial hyperplasias.乳腺导管原位癌中存在p53突变，但上皮增生中不存在。
Cancer Res. 1998 Feb 15;58(4):785-9.
10
Loss of heterozygosity is detected at chromosomes 1p35-36 (NB), 3p25 (VHL), 16p13 (TSC2/PKD1), and 17p13 (TP53) in microdissected apocrine carcinomas of the breast.在乳腺微切割顶泌汗腺癌中，在染色体1p35 - 36（神经母细胞瘤）、3p25（VHL）、16p13（TSC2/PKD1）和17p13（TP53）检测到杂合性缺失。
Mod Pathol. 1999 Dec;12(12):1083-9.

引用本文的文献

1
Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer.乳腺导管原位癌携带有代表浸润性乳腺癌的突变驱动事件。
Mod Pathol. 2017 Jul;30(7):952-963. doi: 10.1038/modpathol.2017.21. Epub 2017 Mar 24.
2
Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast.乳腺导管原位癌的技术评估与基因组格局综述
Breast Cancer Res. 2015 Jun 16;17(1):80. doi: 10.1186/s13058-015-0586-z.
3
Primary squamous cell carcinoma of the endometrium unrelated to human papilloma virus: a molecular study.

本文引用的文献

1
Continued local recurrence of carcinoma 15-25 years after a diagnosis of low grade ductal carcinoma in situ of the breast treated only by biopsy.仅通过活检治疗的乳腺低级别导管原位癌诊断后15至25年，癌灶持续局部复发。
Cancer. 1995 Oct 1;76(7):1197-200. doi: 10.1002/1097-0142(19951001)76:7<1197::aid-cncr2820760715>3.0.co;2-0.
2
Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.乳腺导管原位癌中BRCA1基因区域的等位基因失衡。
Br J Cancer. 1996 Mar;73(5):636-9. doi: 10.1038/bjc.1996.110.
3
Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3.
原发性子宫内膜鳞状细胞癌与人类乳头瘤病毒无关：一项分子研究。
Pathol Oncol Res. 2013 Jul;19(3):495-9. doi: 10.1007/s12253-013-9607-3. Epub 2013 Feb 21.
4
p53 mutations and expression in breast carcinoma in situ.原位乳腺癌中的p53突变与表达
Am J Pathol. 2000 Jan;156(1):183-91. doi: 10.1016/S0002-9440(10)64718-9.
5
Genetic alterations on chromosome 16 and 17 are important features of ductal carcinoma in situ of the breast and are associated with histologic type.16号和17号染色体上的基因改变是乳腺导管原位癌的重要特征，并与组织学类型相关。
Br J Cancer. 1999 Dec;81(8):1410-8. doi: 10.1038/sj.bjc.6693372.
6
Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors.是否存在低 penetrance 的 TP53 等位基因？来自儿童肾上腺皮质肿瘤的证据。 注：“penetrance”一般译为“外显率” ，这里直接保留英文未翻译是因为不确定你原文中是否是特定术语表述，若有特定含义可根据实际情况替换准确翻译。
Am J Hum Genet. 1999 Oct;65(4):995-1006. doi: 10.1086/302575.
7
Allelic imbalance at chromosome 17p13.3 (YNZ22) in breast cancer is independent of p53 mutation or p53 overexpression and is associated with poor prognosis at medium-term follow-up.乳腺癌中17号染色体p13.3区域（YNZ22）的等位基因失衡独立于p53突变或p53过表达，并且与中期随访时的不良预后相关。
Br J Cancer. 1998 Mar;77(5):797-800. doi: 10.1038/bjc.1998.129.
8
Loss of heterozygosity and microsatellite instability in breast hyperplasia. No obligate correlation of these genetic alterations with subsequent malignancy.乳腺增生中的杂合性缺失和微卫星不稳定性。这些基因改变与后续恶性肿瘤之间不存在必然关联。
Am J Pathol. 1997 Jun;150(6):1925-32.
详细的图谱绘制和杂合性缺失分析表明，在染色体带17p13.3的远端区域存在一个与散发性乳腺癌相关的抑制基因座。
Hum Mol Genet. 1995 Nov;4(11):2047-55. doi: 10.1093/hmg/4.11.2047.
4
Allelic loss on a chromosome 17 in ductal carcinoma in situ of the breast.乳腺导管原位癌中17号染色体上的等位基因缺失。
Cancer Res. 1993 Jul 1;53(13):2947-9.
5
The sensitivity of single-strand conformation polymorphism analysis for the detection of single base substitutions.单链构象多态性分析检测单碱基替换的灵敏度。
Genomics. 1993 May;16(2):325-32. doi: 10.1006/geno.1993.1193.
6
Relative efficiency of denaturing gradient gel electrophoresis and single strand conformation polymorphism in the detection of mutations in exons 5 to 8 of the p53 gene.
Oncogene. 1994 Jun;9(6):1739-43.
7
p53 protein expression in mammary ductal carcinoma in situ: relationship to immunohistochemical expression of estrogen receptor and c-erbB-2 protein.乳腺导管原位癌中p53蛋白表达：与雌激素受体及c-erbB-2蛋白免疫组化表达的关系
Hum Pathol. 1993 May;24(5):463-8. doi: 10.1016/0046-8177(93)90157-c.
8
p53 mutations are confined to the comedo type ductal carcinoma in situ of the breast. Immunohistochemical and sequencing data.p53突变局限于乳腺粉刺型导管原位癌。免疫组织化学和测序数据。
Lab Invest. 1994 Jul;71(1):67-72.
9
Evidence for a gene on 17p13.3, distal to TP53, as a target for allele loss in breast tumors without p53 mutations.在17p13.3上，位于TP53远端的一个基因作为无p53突变的乳腺肿瘤中等位基因缺失靶点的证据。
Cancer Res. 1994 Aug 1;54(15):4200-6.
10
The role of TP53 in breast cancer development.TP53在乳腺癌发展中的作用。
Cancer Surv. 1993;18:57-75.