Messina C, Rondelli R, Valsecchi M G, Rossetti F, Miniero R, Meloni G, Locatelli F, Aricò M, Testi A M, Dini G, Arrighini A, Manfredini L, Dallorso S, Porta F, Uderzo C, Santoro N, Werner B, De Rossi G, Loiacono G, Andolina M, Lippi A, Favre C, Amici A, Lo Curto M, Masera G
Centro leucemie Infantili, Università di Padova.
Bone Marrow Transplant. 1996 Nov;18 Suppl 2:40-2.
The role of autologous bone marrow transplantation (ABMT) in childhood ALL after an isolated extramedullary (IE) relapse is controversial. Between December 1984 and November 1995, 52 children underwent ABMT because of an IE relapse. The data were stored in the AIEOP-BMT Registry. Thirty four children were transplanted in 2nd CR; eighteen > 2nd CR. The median duration of 1st CR was 24 (range 3-69) and 18 (range 3-59) months, respectively. The median interval from last CR to ABMT was 6 (range 1-28) and 3 (range 1-81) months, respectively. The 5 year EFS for patients transplanted in 2nd CR was 67.7%, while the 3 year EFS for patients in > 2nd CR was 16.7%. In conclusion, ABMT was an effective treatment in early IE relapse only if performed in 2nd CR.
自体骨髓移植（ABMT）在儿童急性淋巴细胞白血病（ALL）孤立髓外（IE）复发后的作用存在争议。1984年12月至1995年11月期间，52名儿童因IE复发接受了ABMT。数据存储在AIEOP - BMT登记处。34名儿童在第二次完全缓解（2nd CR）时接受移植；18名儿童在第二次完全缓解后（> 2nd CR）接受移植。第一次完全缓解的中位持续时间分别为24（范围3 - 69）个月和18（范围3 - 59）个月。从最后一次完全缓解到ABMT的中位间隔分别为6（范围1 - 28）个月和3（范围1 - 81）个月。第二次完全缓解时接受移植的患者5年无事件生存率（EFS）为67.7%，而第二次完全缓解后接受移植的患者3年EFS为16.7%。总之，ABMT仅在第二次完全缓解时进行才是早期IE复发的有效治疗方法。
