纤维支气管镜检查及支气管肺泡灌洗术用于评估儿童骨髓移植后的肺部浸润情况。

Fiberoptic bronchoscopy and bronchoalveolar lavage for the evaluation of pulmonary infiltrates after BMT in children.

作者信息

Lanino E, Sacco O, Kotitsa Z, Rabagliati A, Castagnola E, Garaventa A, Dallorso S, Gandolfo A, Manfredini L, Venzano P, Savioli C, Macció L, Dini G, Rossi G A

机构信息

BMT Unit, G. Gaslini Children's Research Institute, Genova, Italy.

出版信息

Bone Marrow Transplant. 1996 Nov;18 Suppl 2:117-20.

PMID:8932812

Abstract

Thirty-one fiberoptic bronchoscopies and BAL performed within 4 days after the appearance of pulmonary infiltrates in 28 children who received BMT were reviewed. A causative agent was identified in 67% of patients with diffuse infiltrates (Cytomegalovirus in 8 cases, Pneumocystis carinii in 4) and in 31% of those with localized infiltrates (Aspergillus in 2, bacteria in 2). No relevant side effect was reported. The results obtained from cytological and microbiological testing provided relevant informations for the management of most cases, regardless to the identification of a specific pathogen. We conclude that BAL is a safe diagnostic procedure that should be considered early after the onset of pulmonary complications in BMT recipients.

摘要

回顾了28例接受骨髓移植的儿童在肺部浸润出现后4天内进行的31次纤维支气管镜检查和支气管肺泡灌洗（BAL）。在67%的弥漫性浸润患者中发现了病原体（8例为巨细胞病毒，4例为卡氏肺孢子虫），在31%的局限性浸润患者中发现了病原体（2例为曲霉菌，2例为细菌）。未报告相关副作用。无论是否鉴定出特定病原体，细胞学和微生物学检测结果都为大多数病例的管理提供了相关信息。我们得出结论，BAL是一种安全的诊断程序，在骨髓移植受者出现肺部并发症后应尽早考虑使用。