Petersen J S, Dyrberg T, Damm P, Kühl C, Mølsted-Pedersen L, Buschard K
Hagedorn Research Institute, Gentofte, Denmark.
Diabetologia. 1996 Nov;39(11):1329-33. doi: 10.1007/s001250050578.
We have studied the presence of GAD65 autoantibodies in women with insulin-dependent diabetes mellitus (IDDM) (n = 28) or gestational diabetes (GDM) (n = 139) diagnosed during pregnancy and investigated the temporal relationship between these autoantibodies and the subsequent recurrence or development of IDDM. Among the GDM patients, 4.3% (6 of 139) developed true IDDM during a median follow-up period of 6.3 years (range 4.0-11.0). Of these, 2.2% (3 of 139) were positive for GAD65 autoantibodies at diagnosis of GDM compared to 0% (0 of 27) of healthy pregnant women. All 3 GAD65 autoantibody positive GDM patients subsequently developed IDDM after a median of 14 months (range 4-34). GAD65 autoantibodies were present in 50% (14 of 28) of sera from women with IDDM diagnosed during pregnancy. The non-insulin-requiring remission period was significantly shorter in GAD65 autoantibody positive patients (median 0.5 years [range 0-6.0 years]) than in GAD65 antibody negative patients (median 2.6 years; range 0-9.7 years; p < 0.05). The results suggest that screening for GAD65 autoantibodies in women with GDM or IDDM diagnosed during pregnancy may be useful for predicting the clinical course of the disease.
我们研究了妊娠期间诊断为胰岛素依赖型糖尿病（IDDM）的女性（n = 28）或妊娠糖尿病（GDM）的女性（n = 139）中GAD65自身抗体的存在情况，并调查了这些自身抗体与随后IDDM复发或发展之间的时间关系。在GDM患者中，4.3%（139例中的6例）在中位随访期6.3年（范围4.0 - 11.0年）内发展为真正的IDDM。其中，GDM诊断时2.2%（139例中的3例）GAD65自身抗体呈阳性，而健康孕妇中这一比例为0%（27例中的0例）。所有3例GAD65自身抗体阳性的GDM患者在中位14个月（范围4 - 34个月）后均发展为IDDM。妊娠期间诊断为IDDM的女性血清中，50%（28例中的14例）存在GAD65自身抗体。GAD65自身抗体阳性患者的非胰岛素依赖缓解期（中位0.5年[范围0 - 6.0年]）明显短于GAD65抗体阴性患者（中位2.6年；范围0 - 9.7年；p < 0.05）。结果表明，对妊娠期间诊断为GDM或IDDM的女性进行GAD65自身抗体筛查可能有助于预测疾病的临床进程。
