Takahashi T, Satoh M, Satoh H
Department of Respiratory Medicine, Sapporo City General Hospital.
Intern Med. 1996 Oct;35(10):811-4. doi: 10.2169/internalmedicine.35.811.
A 70-year-old female had an abnormal chest roentgenogram. Infiltrative shadows were recognized in the right lung, and an open lung biopsy (OLB) specimen revealed usual interstitial pneumonia (UIP). Xerostomia, keratoconjunctivitis sicca, and lymphocyte infiltration in salivary glands were consistent with Sjögren's syndrome; she was diagnosed as having pulmonary fibrosis in association with Sjögren's syndrome (SjS-IP). Acute exacerbation occurred and she was successfully treated with corticosteroids. Unilateral exacerbation and UIP in SjS-IP are rare. OLB is useful for diagnosis and to select a pertinent therapy if lung involvement is unilateral in Sjögren's syndrome.
一名70岁女性胸部X线片异常。右肺可见浸润性阴影，开胸肺活检（OLB）标本显示为寻常型间质性肺炎（UIP）。口干、干燥性角结膜炎以及唾液腺淋巴细胞浸润符合干燥综合征；她被诊断为患有与干燥综合征相关的肺纤维化（SjS-IP）。发生了急性加重，经皮质类固醇治疗成功。SjS-IP中的单侧加重和UIP很罕见。如果干燥综合征患者肺部受累为单侧，OLB有助于诊断并选择合适的治疗方法。
