Truter I, Kotze T J
Pharmacy Department, University of Port Elizabeth, South Africa.
J Clin Pharm Ther. 1996 Aug;21(4):237-42. doi: 10.1111/j.1365-2710.1996.tb01144.x.
The primary aim of the study was to investigate the prescribing patterns of selective serotonin re-uptake inhibitors (SSRIs) used on a chronic basis in a defined South African patient population, and to calculate the average prescribed daily doses (PDDs) of selected SSRIs. Prescription data for 2117 patients from various medical schemes who were using antidepressant drugs on a chronic basis were analysed retrospectively. More than 70% of all the patients using antidepressants were females. The tricyclic antidepressants (TCAs) and the SSRIs accounted for approximately 75% of all the antidepressants prescribed. The average age of the patients using SSRIs was 48.1 years (SD = 13.4 years). Fluoxetine was the most frequently prescribed SSRI, accounting for 63.3% of all SSRI prescriptions and 21.9% of all antidepressant prescriptions. The average PDDs of citalopram (23.9 mg), fluoxetine (21.7 mg) and paroxetine (21.1 mg) were slightly higher than their defined daily doses (20 mg for all three drugs). The average PDD of fluvoxamine (93.5 mg) was lower than the DDD (150 mg), but was still within an acceptable dose range. It was concluded that fluoxetine was clearly the drug of choice in treating chronic depression in this patient sample, and that the PDDs used in the patient population studied were in agreement with local and internationally acceptable dosage ranges.
该研究的主要目的是调查在特定南非患者群体中长期使用的选择性5-羟色胺再摄取抑制剂（SSRI）的处方模式，并计算所选SSRI的平均每日处方剂量（PDD）。对来自各种医疗计划的2117名长期使用抗抑郁药物的患者的处方数据进行了回顾性分析。所有使用抗抑郁药的患者中，超过70%为女性。三环类抗抑郁药（TCA）和SSRI约占所有抗抑郁药处方的75%。使用SSRI的患者的平均年龄为48.1岁（标准差=13.4岁）。氟西汀是最常处方的SSRI，占所有SSRI处方的63.3%和所有抗抑郁药处方的21.9%。西酞普兰（23.9毫克）、氟西汀（21.7毫克）和帕罗西汀（21.1毫克）的平均PDD略高于其规定日剂量（这三种药物均为20毫克）。氟伏沙明的平均PDD（93.5毫克）低于规定日剂量（150毫克），但仍在可接受的剂量范围内。得出的结论是，在该患者样本中，氟西汀显然是治疗慢性抑郁症的首选药物，且所研究患者群体中使用的PDD与当地和国际上可接受的剂量范围一致。
