Verrey F, Beron J, Spindler B
Institute of Physiology, University of Zürich, Switzerland.
Miner Electrolyte Metab. 1996;22(5-6):279-92.
The nature and the mechanisms of renal Na,K-ATPase (Na pump) regulation by corticosteroids remain a matter of debate. This is mainly due to the limitations of the experimental approaches, the inhomogeneity of the nephron and the complexity of homeostatic feedback mechanisms. However, 'classical' early and late cellular actions of corticosteroids, which are mineralocorticoid-specific in the collecting duct, can be recognized: The 'early action' is characterized by an increase in the number of active (versus inactive) pumps and/or by a change in their kinetic properties. The 'late action' is characterized by an increase in the number of pumps resulting from, at least in part, an increase in the rate of Na,K-ATPase gene transcription. Sodium delivery into the cells and other elements of the regulatory network play permissive or co-regulatory roles in both early and late actions.
皮质类固醇对肾钠钾ATP酶（钠泵）的调节性质和机制仍存在争议。这主要是由于实验方法的局限性、肾单位的不均一性以及稳态反馈机制的复杂性。然而，皮质类固醇在集合管中具有盐皮质激素特异性的“经典”早期和晚期细胞作用是可以识别的：“早期作用”的特征是活性（与非活性）泵数量增加和/或其动力学特性改变。“晚期作用”的特征是泵数量增加，这至少部分是由于钠钾ATP酶基因转录速率增加所致。钠向细胞内的转运以及调节网络的其他因素在早期和晚期作用中都发挥着允许或共同调节作用。
