Abramowitz J, Suki W N
Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA.
Miner Electrolyte Metab. 1996;22(5-6):336-44.
The plasma membrane Ca-ATPases play an important role in the regulation of intracellular Ca2+ ion concentration by pumping Ca2+ out of the cell into the extracellular fluid at the expense of ATP. These pumps potentially play an important role in the delivery of Ca2+ during mineralization of hard tissues such as bone. The properties of the plasma membrane Ca2+ pump are compared with those of the sarco(endo)plasmic reticulum and the factors regulating pump function are presented. The different gene products for the plasma membrane Ca-ATPases are described as well as their known functional significance. Particular attention is paid on the plasma membrane Ca2+ pumps present in mineralizing tissues and evidence supporting a role for these pumps in the transcellular delivery of Ca2+ during the process of mineralization is also presented.
质膜钙 -ATP 酶通过消耗 ATP 将 Ca²⁺ 泵出细胞进入细胞外液，在调节细胞内 Ca²⁺ 离子浓度方面发挥重要作用。这些泵在诸如骨骼等硬组织矿化过程中 Ca²⁺ 的输送方面可能发挥重要作用。将质膜 Ca²⁺ 泵的特性与肌浆（内质）网的特性进行了比较，并介绍了调节泵功能的因素。描述了质膜钙 -ATP 酶的不同基因产物及其已知的功能意义。特别关注了矿化组织中存在的质膜 Ca²⁺ 泵，并给出了支持这些泵在矿化过程中 Ca²⁺ 的跨细胞输送中发挥作用的证据。
