Bastani B, Gluck S L
Division of Nephrology, St. Louis University Health Sciences Center, MO 63110, USA.
Miner Electrolyte Metab. 1996;22(5-6):396-409.
The diagnosis and classification of distal renal tubular acidosis (distal RTA) have traditionally been made on the basis of the renal response to physiologic maneuvers, providing only indirect information on the underlying pathophysiology. In the past several years significant advances have been made in our understanding of the molecular basis of distal H+/HCO3- secretion and absorption, at the level of individual transporters. With these advances, a new era of classifying disorders of distal acidification at the molecular level has arrived. In this article we review the cellular and molecular basis of normal acidification mechanisms in the distal nephron. We also review the recent information on the molecular basis of derangements in these mechanisms which lead to distal RTA.
远端肾小管酸中毒（远端RTA）的诊断和分类传统上是基于肾脏对生理操作的反应，这仅提供了关于潜在病理生理学的间接信息。在过去几年中，我们在个体转运体水平上对远端H⁺/HCO₃⁻分泌和重吸收的分子基础的理解取得了重大进展。随着这些进展，在分子水平上对远端酸化障碍进行分类的新时代已经到来。在本文中，我们回顾了远端肾单位正常酸化机制的细胞和分子基础。我们还回顾了导致远端RTA的这些机制紊乱的分子基础的最新信息。
