Waalkens-Berendsen D H, Smits-van Prooije A E, Wijnands M V, Bär A
TNO-Nutrition and Food Research Institute, Zeist, The Netherlands.
Regul Toxicol Pharmacol. 1996 Oct;24(2 Pt 2):S237-46. doi: 10.1006/rtph.1996.0104.
Erythritol was fed at dietary concentrations of 0, 2.5, 5, or 10% to Crl:(WI) WU BR rats of both sexes through two successive generations (F0 and F1). Twenty-four rats of each sex were mated in each group. For each generation one litter was reared until the pups were 21 days old. In the 10% erythritol group, food consumption among F0-males and -females was initially significantly reduced until the animals adapted to the erythritol diet during the first week of the study. Thereafter, food intake was higher than in controls. A consistently increased food intake also was seen in F1-males and-females of this dose group. This effect was considered to result from the caloric dilution of the food by erythritol, which has a low physiological energy value. The lower body weight and weight gain of the F0-animals of the 10% erythritol group were attributed to the initially reduced food consumption and occurrence of transient diarrhea until the animals had adapted to the erythritol intake. In the F1-animals of the 10% erythritol group, which were adapted to the treatment from weaning, the rate of body weight gain did not differ from controls. The F1-males and -females of this dose group did, however, have a reduced body weight from weaning, which was attributed to a reduced energy intake among the corresponding F0-dams during Weeks 2 and 3 of lactation. This effect was not seen in the F2-generation. It is concluded that under the conditions of this experiment, the intake of erythritol had no adverse effect on fertility and reproductive performance of parent rats or on the development of their progeny. Gross necropsy and microscopic examination of the parenteral reproductive organs also did not reveal treatment-related changes.
将赤藓糖醇以0%、2.5%、5%或10%的膳食浓度投喂给两代连续的（F0和F1）Crl:(WI)WU BR雌雄大鼠。每组有24只雌雄大鼠进行交配。对于每一代，饲养一窝幼崽直至幼崽21日龄。在10%赤藓糖醇组中，F0代雄性和雌性大鼠的食物消耗量在研究的第一周内最初显著减少，直到动物适应了赤藓糖醇饮食。此后，食物摄入量高于对照组。在该剂量组的F1代雄性和雌性大鼠中也观察到食物摄入量持续增加。这种效应被认为是由于赤藓糖醇对食物的热量稀释所致，赤藓糖醇的生理能量值较低。10%赤藓糖醇组F0代动物较低的体重和体重增加归因于最初食物消耗量的减少以及在动物适应赤藓糖醇摄入之前出现的短暂腹泻。在10%赤藓糖醇组从断奶就适应治疗的F1代动物中，体重增加率与对照组没有差异。然而，该剂量组的F1代雄性和雌性大鼠从断奶起体重就较低，这归因于相应F0代母鼠在哺乳期第2周和第3周能量摄入减少。在F2代中未观察到这种效应。得出的结论是，在本实验条件下，赤藓糖醇的摄入对亲代大鼠的生育力和生殖性能或其后代的发育没有不良影响。对亲代生殖器官的大体尸检和显微镜检查也未发现与治疗相关的变化。
