Hill M, Petrik R, Hampl R, Stárka L
Institute of Endocrinology, Charles University, Prague, Czech Republic.
Horm Metab Res. 1996 Oct;28(10):562-4. doi: 10.1055/s-2007-979853.
The concentrations of the antiandrogenic endogenous steroid epitestosterone (epiT) and of testosterone, dihydrotestosterone (DHT) and androstenedione in the prostate were determined in tissue samples obtained from 21 patients who underwent suprapubic prostatectomy for benign prostatic hyperplasia. Fifteen patients received no hormonal treatment before surgery and the other 6 patients were pretreated for 8 weeks before surgery with an oral dose of 5 mg/day finasteride. The steroids were extracted and separated by high pressure liquid chromatography and determined by specific radioimmunoassays. The concentration of epiT (mean 58.4 +/- 40.4 S.D., range 14.0-144.0 fmol/mg protein) exceeded that of testosterone and was nearly as high as that of DHT. The prostatic tissue from the patients treated with finasteride for 8 weeks showed a significant decrease not only in DHT but also in androstenedione and epiT, whereas the concentration of testosterone increased significantly.
从21例因良性前列腺增生接受耻骨上前列腺切除术的患者获取的组织样本中，测定了前列腺中抗雄激素内源性甾体表睾酮（epiT）以及睾酮、双氢睾酮（DHT）和雄烯二酮的浓度。15例患者术前未接受激素治疗，另外6例患者术前口服5毫克/天非那雄胺进行了8周的预处理。甾体通过高压液相色谱法提取和分离，并通过特异性放射免疫测定法进行测定。epiT的浓度（平均58.4±40.4标准差，范围14.0 - 144.0飞摩尔/毫克蛋白质）超过了睾酮，且几乎与DHT一样高。接受非那雄胺治疗8周的患者的前列腺组织不仅DHT显著降低，而且雄烯二酮和epiT也显著降低，而睾酮浓度则显著升高。
