Sakai A, Fukunami M, Nagareda T, Ohmori M, Kumagai K, Umemoto K, Yamada T, Kondoh N, Minamino T, Kotoh K, Hoki N
Division of Cardiology, Osaka Prefectural Hospital.
J Cardiol. 1996 Oct;28(4):213-20.
Histological findings in the acute phase of myocarditis were evaluated as a prediction of hemodynamic state in the chronic phase in 20 patients with clinical and pathological diagnoses of myocarditis who were followed up with echocardiography for at least 1 year. Endomyocardial biopsy samples were obtained from the left ventricle within 1 year of the onset of symptoms. Azan-Mallory staining was performed on the myocytes, which were categorized as either well stained or poorly stained. The point counting method was used to determine the fraction of each type. The improvement in ejection fraction within 1 year correlated significantly with the fraction of poorly stained myocytes (r = 0.46, p < 0.05). The ejection fraction at biopsy was negatively correlated with the volume fraction of well stained myocytes (r = -0.64, p < 0.01). The staining condition of myocytes may be useful in predicting the hemodynamic recovery of patients with myocarditis.
对20例临床和病理诊断为心肌炎且接受超声心动图随访至少1年的患者，评估心肌炎急性期的组织学表现，以预测慢性期的血流动力学状态。在症状出现1年内从左心室获取心内膜活检样本。对心肌细胞进行阿赞-马洛里染色，将其分为染色良好或染色不良两类。采用点计数法确定每种类型的比例。1年内射血分数的改善与染色不良的心肌细胞比例显著相关（r = 0.46，p < 0.05）。活检时的射血分数与染色良好的心肌细胞体积分数呈负相关（r = -0.64，p < 0.01）。心肌细胞的染色情况可能有助于预测心肌炎患者的血流动力学恢复情况。
