Sornson M W, Wu W, Dasen J S, Flynn S E, Norman D J, O'Connell S M, Gukovsky I, Carrière C, Ryan A K, Miller A P, Zuo L, Gleiberman A S, Andersen B, Beamer W G, Rosenfeld M G
Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093, USA.
Nature. 1996 Nov 28;384(6607):327-33. doi: 10.1038/384327a0.
The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.
显然导致遗传性鼠垂体依赖性侏儒症（Ames侏儒症，df）的基因已被定位克隆，鉴定出一种新的、组织特异性的、配对样同源结构域转录因子，称为垂体特异性转录因子先驱（Prop-1）。df表型是由于生长激素、催乳素或促甲状腺激素产生所需的Pit-1谱系初始决定明显失败，导致畸形发生和无法激活Pit-1基因表达。这些结果表明，一系列组织特异性调节因子负责垂体器官发生中特定细胞谱系的决定和分化。
