Oyabu Y
Department of Urology, Omuta City General Hospital.
Jpn J Antibiot. 1996 Mar;49(3):250-5.
A clinical study on sulbactam/cefoperazone was performed and the following results were obtained. Sulbactam/cefoperazone was administered intravenously to 30 elderly patients with urinary tract infections. Those patients were treated with 1g of sulbactam/cefoperazone 2 times daily. 1. Clinical efficacies in 24 cases of complicated urinary tract infections were excellent in 8, moderate in 11 and poor in 5, with an overall efficacy rate of 79.2%. As to bacteriological responses, 20 of 25 strains identified in the complicated urinary tract infections were eradicated, with an eradication rate of 80%. 2. Clinical efficacies in two cases of acute uncomplicated pyelonephritis were excellent in 1 and moderate in 1, with an overall efficacy rate of 100%. Bacteriologically, two of the strains in the acute uncomplicated pyelonephritis was eradicated, with an eradication rate of 100%. 3. Safety evaluation was made in all 30 patients received sulbactam/cefoperazone. No adverse reactions were observed in any cases. As to laboratory test results, slight elevation of GPT was noted in 1 patient. In conclusion, sulbactam/cefoperazone is considered as a clinically useful antibiotics in the treatment of urinary tract infections with elderly patients.
进行了一项关于舒巴坦/头孢哌酮的临床研究，并获得了以下结果。对30例老年尿路感染患者静脉注射舒巴坦/头孢哌酮。这些患者每日2次接受1g舒巴坦/头孢哌酮治疗。1. 24例复杂性尿路感染的临床疗效中，8例为优，11例为中，5例为差，总有效率为79.2%。在细菌学反应方面，复杂性尿路感染中鉴定出的25株菌株中有20株被根除，根除率为80%。2. 2例急性非复杂性肾盂肾炎的临床疗效中，1例为优，1例为中，总有效率为100%。在细菌学方面，急性非复杂性肾盂肾炎中的2株菌株被根除，根除率为100%。3. 对所有30例接受舒巴坦/头孢哌酮治疗的患者进行了安全性评估。所有病例均未观察到不良反应。关于实验室检查结果，1例患者谷丙转氨酶轻度升高。总之，舒巴坦/头孢哌酮被认为是治疗老年患者尿路感染的一种临床有用的抗生素。
