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硬膜外阿片类药物治疗慢性非恶性疼痛:对当前经验的批判

Epidural opioid therapy for chronic nonmalignant pain: critique of current experience.

作者信息

Bedder M D

机构信息

Advanced Pain Management Group, Inc., Portland, Oregon 97225, USA.

出版信息

J Pain Symptom Manage. 1996 Jun;11(6):353-6. doi: 10.1016/0885-3924(96)00007-3.

DOI:10.1016/0885-3924(96)00007-3
PMID:8935138
Abstract

The current use of epidural catheter techniques for nonmalignant pain follows directly from its successful use of treating intractable malignant pain states. Long-term studies are confirming the safety of epidural infusions of morphine and local anesthetics. Limitations of this technique related to technical catheter considerations, neuropathic pain states, and cost considerations are being reevaluated as more information is developed. Epidural infusions in nonmalignant pain may prove their value in prolonged treatments for conditions that may resolve in time. They are also being utilized increasingly as screening tools prior to implanting permanent infusion pump systems.

摘要

目前硬膜外导管技术用于非恶性疼痛,直接源于其在治疗顽固性恶性疼痛状态方面的成功应用。长期研究正在证实硬膜外输注吗啡和局部麻醉剂的安全性。随着更多信息的积累,与导管技术、神经性疼痛状态及成本相关的该技术局限性正在重新评估。硬膜外输注在非恶性疼痛中,可能在对可随时间缓解的病症的长期治疗中证明其价值。它们也越来越多地被用作植入永久性输注泵系统之前的筛查工具。

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引用本文的文献

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The efficacy and safety of epidural morphine/hydromorphone in the treatment of intractable postherpetic neuralgia: A single-center, double-blinded, randomized controlled, prospective, and non-inferiority study.硬膜外注射吗啡/氢吗啡酮治疗顽固性带状疱疹后神经痛的疗效与安全性:一项单中心、双盲、随机对照、前瞻性非劣效性研究。
Front Pharmacol. 2022 Dec 6;13:1051357. doi: 10.3389/fphar.2022.1051357. eCollection 2022.