Ando I, Komine M, Otsuka F, Kukita A
Department of Dermatology, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan.
J Dermatol. 1996 Apr;23(4):225-9. doi: 10.1111/j.1346-8138.1996.tb04003.x.
In lesions of malignant melanoma, melanoma cells are exposed to various cytokines produced by inflammatory reactions. As a result, transformation of melanoma cells is expected to occur. We studied alterations in human melanoma cell line ganglioside composition after exposing melanoma cell lines to interferon (IFN)-gamma, interleukin (IL)-2, and IL-4 by biochemical methods. IFN-gamma increases the ratio of a-series gangliosides and the ratio of GM3/GD3. This suggests an alteration of immunoreactivity, a decrease in ganglioside sialyltransferase II activity, and an decrease in the malignant character of these cells. The alteration of the ganglioside profile varied among cytokines and cell lines. The progression of malignant melanoma may be influenced by reciprocal interactions between the melanoma cells and the host immune system.
在恶性黑色素瘤病变中，黑色素瘤细胞会接触到炎症反应产生的各种细胞因子。因此，预计黑色素瘤细胞会发生转化。我们通过生化方法研究了将黑色素瘤细胞系暴露于干扰素（IFN）-γ、白细胞介素（IL）-2和IL-4后，人黑色素瘤细胞系神经节苷脂组成的变化。IFN-γ增加了a系列神经节苷脂的比例以及GM3/GD3的比例。这表明免疫反应性发生改变，神经节苷脂唾液酸转移酶II活性降低，且这些细胞的恶性特征减弱。神经节苷脂谱的改变在不同细胞因子和细胞系之间存在差异。恶性黑色素瘤的进展可能受到黑色素瘤细胞与宿主免疫系统之间相互作用的影响。
