一氧化氮介导的恰加斯病免疫球蛋白G的负性肌力作用

Negative inotropic effect of chagasic IgG mediated by nitric oxide.

作者信息

Vila Echagüe A, Sterin-Borda L

机构信息

Pharmacology Department, University of Buenos Aires, Argentina.

出版信息

Acta Physiol Pharmacol Ther Latinoam. 1996;46(1):23-32.

PMID:8935488

Abstract

In this paper we analyse the interaction of IgG from T. cruzi infected patients with cardiac muscarinic acetylcholine receptors (mAChRs). Human chagasic IgG, activating M2 mAChR simulated the agonist actions excerting negative inotropic effect and stimulation of nitric oxide synthase (NOS). Inhibitors of phospholipase C, protein kinase C, calcium/calmodulin, NOS and guanylate cyclase activities prevented the chagasic effects upon contractility and NOS activity.

摘要

在本文中，我们分析了来自克氏锥虫感染患者的IgG与心肌毒蕈碱型乙酰胆碱受体（mAChRs）之间的相互作用。人类恰加斯病IgG激活M2 mAChR，模拟激动剂作用，发挥负性肌力作用并刺激一氧化氮合酶（NOS）。磷脂酶C、蛋白激酶C、钙/钙调蛋白、NOS和鸟苷酸环化酶活性的抑制剂可阻止恰加斯病对收缩性和NOS活性的影响。