Froehlich P M, Ross G
J Chromatogr. 1977 Jul 11;137(1):135-43. doi: 10.1016/s0021-9673(00)89248-1.
A rapid, sensitive and selective analytical procedure for phencyclidine and one of its metabolites in urine has bee developed. Three techniques have been studied for extraction of the drug from the biological matrix: (a) reversed-phase XAD resin, (b) charcoal absorption, and (c) solvent extraction using chloroform. Temperature-programmed gas chromatography was used to quantitate the illicit drug. Solvent extraction appears to offer the most efficient separation of the drug and its metabolite, as the recovery was 94% and the technique required only 7-8 min per sample. Reversedphase column extraction is also quite useful; although more time-consuming for an indivisual sample, it would be useful for screening purposes.
已开发出一种用于尿液中苯环利定及其一种代谢物的快速、灵敏且选择性的分析方法。研究了三种从生物基质中提取该药物的技术：(a)反相XAD树脂，(b)活性炭吸附，以及(c)用氯仿进行溶剂萃取。采用程序升温气相色谱法定量分析这种违禁药物。溶剂萃取似乎能最有效地分离该药物及其代谢物，回收率为94%，且该技术每个样品仅需7 - 8分钟。反相柱萃取也非常有用；虽然单个样品耗时更长，但用于筛查目的会很有用。
