Puri A S, Kumar M, Khan E M, Pandey R, Aggarwal R, Naik S, Choudhuri G, Naik S R
Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow.
Indian J Gastroenterol. 1996 Apr;15(2):46-8.
Immunoproliferative small intestinal disease (IPSID) is a poorly recognized cause of malabsorption syndrome in India. Clinicopathological features of five patients with IPSID seen over a two-year period are described. Our data suggest that IPSID is commonly misdiagnosed as intestinal tuberculosis due to lack of awareness and reluctance to obtain small bowel biopsies. Empirical institution of anti-tubercular chemotherapy not only leads to delayed diagnosis but also possibly alters the natural history of the disease, resulting in an intermediate phase of amelioration followed by a terminal phase of lymphomatous transformation. The disease is therefore usually diagnosed at an advanced stage and hence is associated with a relatively poor outcome.
免疫增殖性小肠疾病（IPSID）在印度是一种较少被认识到的吸收不良综合征病因。本文描述了两年间所见的5例IPSID患者的临床病理特征。我们的数据表明，由于缺乏认识以及不愿进行小肠活检，IPSID常被误诊为肠结核。经验性应用抗结核化疗不仅会导致诊断延迟，还可能改变疾病的自然病程，导致病情缓解的中间阶段，随后进入淋巴瘤转化的终末期。因此，该病通常在晚期才被诊断出来，故而预后相对较差。
