Philipps A F
Department of Pediatrics, University of Arizona College of Medicine, Tucson 85724, U.S.A.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1996 Jan-Feb;37(1):1-10.
Insulin-like growth factors (IGF's) are mitogenic peptides bearing homology to proinsulin. IGF's are synthesized by many cell types in mammals and have been implicated as major factors controlling growth and differentiation during fetal life, infancy and childhood. Experimental evidence for these assertions is presented, using data from animal and human studies. The effects of IGF's on normal and abnormal growth processes are discussed, and specific examples are presented of disorders related to abnormal IGF production encountered in pediatric-age patients. Discussion is also included regarding the role of milk-borne IGF for the suckling. Lastly, future uses for IGF's are mentioned, with specific examples given for treating disorders, such as short stature and diabetes due to insulin resistance.
胰岛素样生长因子（IGF）是与胰岛素原具有同源性的促有丝分裂肽。IGF由哺乳动物的多种细胞类型合成，并被认为是控制胎儿期、婴儿期和儿童期生长与分化的主要因素。本文利用动物和人体研究的数据，为这些论断提供了实验证据。讨论了IGF对正常和异常生长过程的影响，并列举了儿科患者中与IGF产生异常相关疾病的具体实例。还讨论了母乳中IGF对哺乳婴儿的作用。最后，提及了IGF未来的应用，给出了治疗诸如身材矮小和胰岛素抵抗所致糖尿病等疾病的具体实例。
