多胺对四膜虫鸟氨酸脱羧酶活性的调控以及抗酶的缺失
Control of ornithine decarboxylase activity by polyamines and absence of antizyme in Tetrahymena.
作者信息
Koguchi K, Murakami Y, Hayashi S
机构信息
Department of Nutrition, Jikei University School of Medicine, Tokyo, Japan.
出版信息
Comp Biochem Physiol B Biochem Mol Biol. 1996 Jan;113(1):157-62. doi: 10.1016/0305-0491(95)02017-9.
PMID:8936049
Abstract
- In cells of Tetrahymena pyriformis and thermophila, ODC activity was significantly suppressed but ODC decay was not stimulated by putrescine. 2. Free antizyme and ODC-antizyme complex were both not detected in extracts of cells of T. pyriformis treated with putrescine. 3. It was concluded that in Tetrahymena, unlike vertebrate cells, ODC is not subject to polyamine-induced destabilization mediated by antizyme.
摘要
- 在梨形四膜虫和嗜热栖热菌的细胞中，鸟氨酸脱羧酶（ODC）活性被显著抑制，但腐胺并未刺激ODC的降解。2. 在经腐胺处理的梨形四膜虫细胞提取物中，未检测到游离的抗酶和ODC-抗酶复合物。3. 得出的结论是，与脊椎动物细胞不同，在四膜虫中，ODC不受抗酶介导的多胺诱导的不稳定作用影响。
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