Ryan P M, Kelly J P, Chambers P L, Leonard B E
Department of Pharmacology, University College, Galway, Ireland.
Pharmacol Toxicol. 1996 Nov;79(5):238-40. doi: 10.1111/j.1600-0773.1996.tb00266.x.
Oxotremorine is a muscarinic receptor agonist that induces a variety of physiological and behavioural effects including hypothermia in mice. These effects are antagonized dose-dependently by classical anticholinergic compounds such as atropine. Although the oxotremorine-induced hypothermic response has been demonstrated in mice, few studies of the effects of this muscarinic agonist have been made in the rat. The following studies were made in male Sprague Dawley rats: 1. an investigation of the dose-response relationship between oxotremorine and hypothermia; 2. an examination of the effect of housing on the oxotremorine-induced hypothermic response, and 3, an investigation of the acute administration of various doses of atropine sulphate on the hypothermia caused by oxotremorine. The results indicate that the dose-response relationship between oxotremorine and the antagonism of hypothermia is similar in rat as it is in mice. The results also showed that this effect did not occur in group-housed animals.
氧化震颤素是一种毒蕈碱受体激动剂，可诱导多种生理和行为效应，包括使小鼠体温过低。这些效应会被阿托品等经典抗胆碱能化合物剂量依赖性地拮抗。尽管氧化震颤素诱导的体温过低反应已在小鼠中得到证实，但对这种毒蕈碱激动剂在大鼠中的作用研究较少。以下研究是在雄性斯普拉格-道利大鼠中进行的：1. 研究氧化震颤素与体温过低之间的剂量反应关系；2. 考察饲养方式对氧化震颤素诱导的体温过低反应的影响；3. 研究急性给予不同剂量硫酸阿托品对氧化震颤素引起的体温过低的影响。结果表明，氧化震颤素与体温过低拮抗作用之间的剂量反应关系在大鼠和小鼠中相似。结果还表明，这种效应在群居动物中未出现。
