Litman R S, Zerngast B A
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, NY, USA.
J Am Osteopath Assoc. 1996 Oct;96(10):616-8.
An 11-year-old, 25-kg girl with congenital myelomeningocele was scheduled for posterior spinal fusion because of progressive scoliosis. After induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride, her cardiac rhythm progressed to asystole. Although given ephedrine, epinephrine, and atropine sulfate, the patient's normal heart rhythm could not be restored until calcium chloride was administered. A review of the medical literature indicates that the optimal treatment for acute beta-blocker toxicity is intravenous glucagon. Calcium administration should also be considered. Acute esmolol toxicity may be self-limiting because of its extremely short half-life.
一名11岁、体重25千克的先天性脊髓脊膜膨出女童因进行性脊柱侧凸计划接受后路脊柱融合术。在全身麻醉诱导并给予标准剂量的静脉注射盐酸艾司洛尔后，她的心律进展为心搏停止。尽管给予了麻黄碱、肾上腺素和硫酸阿托品，但直到给予氯化钙后，患者的正常心律才得以恢复。医学文献回顾表明，急性β受体阻滞剂中毒的最佳治疗方法是静脉注射胰高血糖素。也应考虑给予钙剂。由于艾司洛尔半衰期极短，急性艾司洛尔中毒可能具有自限性。
