Gasser T, Müller-Myhsok B, Supala A, Zimmer E, Wieditz G, Wszolek Z K, Vieregge P, Bonifati V, Oertel W H
Neurologische Klinik, Klinikum Groshadern, Ludwig-Maximilians-Universität, München, Germany.
J Neurol Neurosurg Psychiatry. 1996 Nov;61(5):518-20. doi: 10.1136/jnnp.61.5.518.
The frequency of the CYP2D6B allele of the gene for debrisoquine 4-hydroxylase was studied in 115 patients with sporadic idiopathic Parkinson's disease, 55 of their healthy siblings, 63 patients with familial Parkinson's disease, 55 unaffected relatives, and 92 patients with Alzheimer's disease and 73 age matched healthy controls. By contrast with several previous studies, no significant variation of allele frequencies could be found between any of the groups studied. The results argue against a significant role of the CYP2D6 gene in the aetiology of sporadic and familial idiopathic parkinsonism in this patient population.
对115例散发性特发性帕金森病患者、其中55例健康同胞、63例家族性帕金森病患者、55例未患病亲属、92例阿尔茨海默病患者以及73例年龄匹配的健康对照者，研究了去甲丙咪嗪4 - 羟化酶基因的CYP2D6B等位基因频率。与之前的几项研究相反，在所研究的任何组之间均未发现等位基因频率有显著差异。结果表明，在该患者群体中，CYP2D6基因在散发性和家族性特发性帕金森病的病因学中不起重要作用。
