Mazzone T
Rush Medical College, Chicago, IL 60612, USA.
Curr Opin Lipidol. 1996 Oct;7(5):303-7. doi: 10.1097/00041433-199610000-00008.
Results of numerous studies using varied experimental approaches have established a role for macrophage-derived apolipoprotein E in modulating cholesterol balance in the arterial wall, thereby potentially modulating progression or regression of the vessel wall atherosclerotic lesion. Macrophage-derived apolipoprotein E could also act on the vessel wall by modulating the aggregability of platelets and the proliferation of lymphocytes. In addition, macrophage-derived apolipoprotein E interacts with extracellular matrix and such interactions could influence the retention of lipoproteins in the vessel wall, the bioavailability of cytokines and growth factors sequestered in the extracellular matrix and the regulation of arterial smooth muscle cell growth by matrix components.
众多采用不同实验方法的研究结果表明，巨噬细胞源性载脂蛋白E在调节动脉壁胆固醇平衡中发挥作用，从而可能调节血管壁动脉粥样硬化病变的进展或消退。巨噬细胞源性载脂蛋白E还可通过调节血小板的聚集性和淋巴细胞的增殖作用于血管壁。此外，巨噬细胞源性载脂蛋白E与细胞外基质相互作用，这种相互作用可能影响脂蛋白在血管壁中的潴留、细胞外基质中封存的细胞因子和生长因子的生物利用度以及基质成分对动脉平滑肌细胞生长的调节。
