Willott J F
J Comp Physiol Psychol. 1977 Aug;91(4):937-41. doi: 10.1037/h0077372.
Previous experiments have indicated that interference with somatosensory feedback from convulsive movements may lessen the severity of audiogenic seizures in susceptible rodents. For further investigation of this phenomenon, mice were partially immobilized with tubocurarine chloride to attenuate convulsive movements and somatosensory input associated with such movements. In Experiment 1, seizures of mice injected with .15 mg/kg were evaluated behaviorally and compared with seizures of saline-injected litter-mates. The likelihood of clonic-tonic seizures in curarized mice was as high as that of control mice, although convulsive movements were somewhat less violent and seizure fatalities were markedly reduced. In Experiment 2, seizures of mice given .25 mg/kg were evaluated with electroencephalography, and records were compared with those of controls. Despite the near absence of behavioral signs of convulsions, electroencephalograms of curarized mice showed that audiogenic seizures readily occurred. The findings suggest that audiogenic seizures are centrally "programmed" and do not require feedback from convulsive movements. However, it may be possible to disrupt the central "program" by introducing appropriate somatosensory input not normally encountered during audiogenic seizures.
先前的实验表明，干扰抽搐运动的体感反馈可能会减轻易感啮齿动物听源性癫痫发作的严重程度。为了进一步研究这一现象，用氯化筒箭毒碱使小鼠部分固定，以减弱抽搐运动及与此类运动相关的体感输入。在实验1中，对注射了0.15毫克/千克的小鼠的癫痫发作进行行为评估，并与注射生理盐水的同窝小鼠的癫痫发作情况进行比较。箭毒化小鼠阵挛 - 强直发作的可能性与对照小鼠一样高，尽管抽搐运动的剧烈程度有所降低，且癫痫致死率明显降低。在实验2中，用脑电图对注射了0.25毫克/千克的小鼠的癫痫发作进行评估，并将记录与对照组的记录进行比较。尽管几乎没有抽搐的行为迹象，但箭毒化小鼠的脑电图显示听源性癫痫发作很容易发生。这些发现表明，听源性癫痫发作是由中枢“编程”的，不需要抽搐运动的反馈。然而，通过引入听源性癫痫发作期间通常不会遇到的适当体感输入，可能有可能破坏中枢“程序”。
