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The role of folate, choline, and methionine in carcinogenesis induced by methyl-deficient diets.

作者信息

Henning S M, Swendseid M E

机构信息

UCLA, School of Public Health, Division of Community Health Sciences 90095, USA.

出版信息

Adv Exp Med Biol. 1996;399:143-55. doi: 10.1007/978-1-4613-1151-5_11.

DOI:10.1007/978-1-4613-1151-5_11
PMID:8937554
Abstract
摘要

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The role of folate, choline, and methionine in carcinogenesis induced by methyl-deficient diets.叶酸、胆碱和蛋氨酸在甲基缺乏饮食诱导的致癌作用中的角色。
Adv Exp Med Biol. 1996;399:143-55. doi: 10.1007/978-1-4613-1151-5_11.
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Methyl donors in the diet and responses to chemical carcinogens.
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Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats.饮食诱导甲基供体缺乏大鼠淋巴细胞中的DNA损伤及核苷酸代谢改变。
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Effects of vitamin B12 and folate deficiencies on DNA methylation and carcinogenesis in rat liver.维生素B12和叶酸缺乏对大鼠肝脏DNA甲基化及致癌作用的影响。
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Methionine metabolism and liver disease.蛋氨酸代谢与肝脏疾病
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Methyl group deficiency in hepatocarcinogenesis.肝癌发生过程中的甲基基团缺乏
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In vivo methylation capacity is not impaired in healthy men during short-term dietary folate and methyl group restriction.在短期饮食中限制叶酸和甲基的情况下,健康男性的体内甲基化能力并未受损。
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Male rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity.喂食缺乏甲基和叶酸且添加或不添加烟酸的饮食的雄性大鼠会发生肝癌,同时伴有组织烟酰胺腺嘌呤二核苷酸(NAD)浓度降低和聚(ADP - 核糖)聚合酶活性改变。
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Methyl-donor deficiency in adolescence affects memory and epigenetic status in the mouse hippocampus.青春期甲基供体缺乏会影响小鼠海马体的记忆和表观遗传状态。
Genes Brain Behav. 2015 Mar;14(3):301-9. doi: 10.1111/gbb.12207. Epub 2015 Mar 25.

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Associations between dietary intake of choline and betaine and lung cancer risk.
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Choline and betaine intake and risk of breast cancer among post-menopausal women.胆碱和甜菜碱的摄入与绝经后妇女乳腺癌的风险。
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