Oishi M, Mochizuki Y, Hara M, Yoshihashi H, Takasu T
Department of Neurology, Nihon University School of Medicine, Tokyo, Japan.
Clin Neuropharmacol. 1996 Dec;19(6):526-31. doi: 10.1097/00002826-199619060-00007.
The present study was designed to examine the effects of sodium ozagrel on hemostatic markers and cerebral blood flow in lacunar infarction. Ten cases of lacunar infarction in which sodium ozagrel was given (administered group), 10 cases of lacunar infarction in which sodium ozagrel was not given (nonadministered group), and 10 age-matched controls in which cerebrovascular diseases were absent but risk factors were similar to those of the patients (control group) were studied. Intravenous infusion of 80 mg of sodium ozagrel was done twice a day for 2 weeks. Platelet factor 4, beta-thromboglobulin, and fibrinopeptide A were significantly higher in the administered and nonadministered groups than in the control group at the time of admission. Platelet factor 4, beta-thromboglobulin, fibrinopeptide A, and thromboxane B2 were decreased significantly by the administration of sodium ozagrel. The blood flow in the cerebral cortex was significantly lower in the administered and nonadministered groups than in the control group. The blood flows around the infarcted area, in the cerebral cortex, and in the cerebral white matter were significantly increased by the administration of sodium ozagrel. Sodium ozagrel is considered to decrease platelet aggregation and increase cerebral blood flow by decreasing thromboxane A2, which has a platelet-aggregating and a vasoconstricting action. Sodium ozagrel is considered to be effective in the acute phase of lacunar infarction.
本研究旨在探讨奥扎格雷钠对腔隙性脑梗死止血指标及脑血流量的影响。研究了10例接受奥扎格雷钠治疗的腔隙性脑梗死患者（给药组）、10例未接受奥扎格雷钠治疗的腔隙性脑梗死患者（未给药组）以及10例年龄匹配、无脑血管疾病但危险因素与患者相似的对照者（对照组）。每天静脉输注80毫克奥扎格雷钠，共2周。入院时，给药组和未给药组的血小板第4因子、β-血小板球蛋白和纤维蛋白肽A显著高于对照组。给予奥扎格雷钠后，血小板第4因子、β-血小板球蛋白、纤维蛋白肽A和血栓素B2显著降低。给药组和未给药组的大脑皮质血流量显著低于对照组。给予奥扎格雷钠后，梗死灶周围、大脑皮质和脑白质的血流量显著增加。奥扎格雷钠被认为可通过降低具有血小板聚集和血管收缩作用的血栓素A2来减少血小板聚集并增加脑血流量。奥扎格雷钠被认为在腔隙性脑梗死急性期有效。
