Martinou J C, Sadoul R
Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development S.A, Switzerland.
Curr Opin Neurobiol. 1996 Oct;6(5):609-14. doi: 10.1016/s0959-4388(96)80092-4.
The past year has witnessed significant advances in our understanding of the mechanisms that kill neurons during programmed cell death. The executioners are members of a family of proteases founded by ced-3, the product of a gene that is required for programmed cell death in the nematode Caenorhabditis elegans, and by mammalian interleukin-1 beta-converting enzyme. These proteases represent interesting novel targets for the therapy of acute and chronic pathologies of the nervous system associated with neuronal death.
过去一年里，我们对程序性细胞死亡过程中杀死神经元的机制有了重大认识进展。刽子手是一类蛋白酶家族的成员，该家族由线虫秀丽隐杆线虫程序性细胞死亡所需基因的产物ced-3以及哺乳动物白细胞介素-1β转换酶开创。这些蛋白酶是治疗与神经元死亡相关的急慢性神经系统疾病的有趣新靶点。
