Hodgskinson R, Njeh C F, Whitehead M A, Langton C M
Centre for Metabolic Bone Disease, Hull, UK.
Phys Med Biol. 1996 Nov;41(11):2411-20. doi: 10.1088/0031-9155/41/11/012.
There is growing interest in assessing the clinical value of ultrasound in the prediction and management of osteoporosis. However, the mechanism of ultrasound propagation in cancellous bone is not well understood. The Biot theory is one approach to modelling the interaction of sound waves with cancellous structure, and porosity is one of its input parameters. In this paper we report the relationship between broadband ultrasonic attenuation (BUA) corrected for specimen thickness (nBUA) and porosity in a porous Perspex cancellous bone mimic, a stereolithography cancellous bone mimic and in natural human and bovine tissue. nBUA and porosity have a non-linear parabolic relationship. The maximum nBUA value (nBUAmax) occurs at approximately 30% porosity in the Perspex mimic, approximately 70% in the stereolithography mimic and approximately 75% in natural cancellous bone. We discuss the effect of structure on the form of the nBUA-porosity relationship.
评估超声在骨质疏松症预测和管理中的临床价值正受到越来越多的关注。然而，超声在松质骨中的传播机制尚未得到充分理解。比奥理论是一种模拟声波与松质结构相互作用的方法，孔隙率是其输入参数之一。在本文中，我们报告了在多孔有机玻璃松质骨模拟物、立体光刻松质骨模拟物以及天然人类和牛组织中，经样本厚度校正的宽带超声衰减（BUA，即nBUA）与孔隙率之间的关系。nBUA与孔隙率呈非线性抛物线关系。在有机玻璃模拟物中，最大nBUA值（nBUAmax）出现在孔隙率约为30%时；在立体光刻模拟物中约为70%；在天然松质骨中约为75%。我们讨论了结构对nBUA-孔隙率关系形式的影响。
