Petrikovsky B, Schneider E
North Shore University Hospital-NYU School of Medicine, New York, USA.
Prenat Diagn. 1996 Oct;16(10):938-40. doi: 10.1002/(SICI)1097-0223(199610)16:10<938::AID-PD964>3.0.CO;2-S.
This study reports the maternal, fetal, and neonatal outcomes in cases with hypoplastic umbilical artery. The sonographic finding of a three-vessel umbilical cord showing an artery-to-artery diameter difference of more than 50 per cent was defined as hypoplastic umbilical artery. All fetuses diagnosed with hypoplastic umbilical artery underwent genetic amniocentesis and ultrasound. Fetal, maternal, and neonatal outcomes were analysed. Twelve fetuses with hypoplastic umbilical artery were detected over a 6-year period (1989-1995). Associated abnormalities included trisomy 18 (one case), polyhydramnios (three cases), congenital heart disease (one case), and fetal growth restriction (two cases). Maternal diabetes was detected in four cases. The pregnancy was terminated in one case; one neonate with severe fetal growth restriction expired; and one survived with congenital heart disease. The presence of hypoplastic umbilical artery was associated with increased perinatal morbidity and congenital abnormalities. Diabetes was frequently detected. Fetal surveillance and echocardiography are indicated in cases of hypoplastic umbilical artery.
本研究报告了脐动脉发育不全病例的孕产妇、胎儿及新生儿结局。超声检查发现三血管脐带的两条动脉直径差异超过50%被定义为脐动脉发育不全。所有诊断为脐动脉发育不全的胎儿均接受了基因羊膜穿刺术和超声检查。分析了胎儿、孕产妇及新生儿结局。在1989年至1995年的6年期间共检测到12例脐动脉发育不全胎儿。相关异常包括18三体综合征（1例）、羊水过多（3例）、先天性心脏病（1例）及胎儿生长受限（2例）。4例孕妇检测出患有糖尿病。1例终止妊娠；1例患有严重胎儿生长受限的新生儿死亡；1例患有先天性心脏病的新生儿存活。脐动脉发育不全与围产期发病率增加及先天性异常有关。糖尿病经常被检测到。对于脐动脉发育不全病例，建议进行胎儿监测和超声心动图检查。
