降钙素基因相关肽（8 - 37）对大鼠脊髓中的降钙素基因相关肽无拮抗作用。

Calcitonin gene-related peptide (8-37) does not antagonize calcitonin gene-related peptide in rat spinal cord.

作者信息

Xu X J, Wiesenfeld-Hallin Z

机构信息

Department of Medical Laboratory Sciences and Technology, Section of Clinical Neurophysiology, Karolinska Institute, Huddinge University Hospital, Sweden.

出版信息

Neurosci Lett. 1996 Feb 9;204(3):185-8. doi: 10.1016/0304-3940(96)12351-x.

DOI:10.1016/0304-3940(96)12351-x

PMID:8938261

Abstract

We have examined the effects of intrathecal (i.t.) human calcitonin gene-related peptide (hCGRP) and its C-terminal fragment hCGRP(8-37), a proposed CGRP antagonist, on the flexor reflex in decerebrate, spinalized, unanesthetized rats. I.t. hCGRP at 26 pmol caused a moderate facilitation of the reflex which was not antagonized by hCGRP(8-37) at doses ranging from 26 pmol to 5.2 nmol. Furthermore, hCGRP(8-37) by itself facilitated the reflex, with no signs of inhibition. It is concluded that the spinal CGRP receptor mediating the spinal facilitatory effect of hCGRP is not antagonized by hCGRP(8-37). Thus, it is unlikely that hCGRP(8-37) can be useful as a spinal analgesic.

摘要

我们研究了鞘内注射人降钙素基因相关肽（hCGRP）及其C端片段hCGRP（8-37）（一种假定的CGRP拮抗剂）对去大脑、脊髓横断、未麻醉大鼠屈肌反射的影响。26 pmol的鞘内hCGRP引起反射的适度易化，在26 pmol至5.2 nmol剂量范围内的hCGRP（8-37）并未拮抗这种易化作用。此外，hCGRP（8-37）自身也能易化反射，没有抑制迹象。结论是，介导hCGRP脊髓易化作用的脊髓CGRP受体不会被hCGRP（8-37）拮抗。因此，hCGRP（8-37）不太可能用作脊髓镇痛药。